L-carnitine supplementation for the management of fatigue in patients with hypothyroidism on levothyroxine treatment: a randomized, double-blind, placebo-controlled trial

A randomized, double-blind, placebo-controlled trial investigated the effects of L-carnitine supplementation on fatigue in hypothyroid patients undergoing levothyroxine treatment. Sixty patients (mean age 50.0 ± 9.2 years; 3 males, 57 females) experiencing persistent fatigue (Fatigue Severity Scale [FSS] score ≥36) were randomized to receive either L-carnitine (990 mg twice daily;