Is L-methionine a trigger factor for Alzheimer’s-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice

This animal study investigated the effects of elevated L-methionine levels on neurodegeneration, specifically looking at Alzheimer's-like pathologies in wild-type mice. The study found that high methionine levels led to increased amyloid-β oligomer formation, tau phosphorylation, and disruption in synaptic proteins, mimicking neurodegenerative changes associated with Alzheimer's disease. The findings suggest