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Tag: tau phosphorylation

Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer’s disease

This review explores quercetin’s neuroprotective mechanisms in Alzheimer’s disease (AD). Quercetin, a flavonoid with antioxidant properties, mitigates oxidative stress by scavenging reactive oxygen species and modulates signaling pathways such as Nrf2, JNK, MAPK, and PI3K/Akt. These actions reduce neuroinflammation, inhibit amyloid-beta aggregation, and prevent tau hyperphosphorylation. Additionally, quercetin influences gene

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June 26, 2025 No Comments

Is L-methionine a trigger factor for Alzheimer’s-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice

This animal study investigated the effects of elevated L-methionine levels on neurodegeneration, specifically looking at Alzheimer’s-like pathologies in wild-type mice. The study found that high methionine levels led to increased amyloid-β oligomer formation, tau phosphorylation, and disruption in synaptic proteins, mimicking neurodegenerative changes associated with Alzheimer’s disease. The findings suggest

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June 26, 2025 No Comments