Increased ROS Generation and p53 Activation in Alpha-Lipoic Acid-Induced Apoptosis of Hepatoma Cells
This 2006 study investigates the pro-apoptotic effects of alpha-lipoic acid (α-LA) on hepatoma cell lines FaO and HepG2. Treatment with α-LA resulted in inhibited cell proliferation, decreased cyclin A expression, and increased levels of cell cycle inhibitors p21^Cip1 and p27^Kip1, leading to cell cycle arrest. Apoptosis was characterized by DNA
June 26, 2025
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