ROS Archives - Well Referenced

Salinomycin: A new paradigm in cancer therapy

This comprehensive review discusses salinomycin, a polyether antibiotic identified as a potent agent against cancer stem cells (CSCs) and multidrug-resistant tumors. Salinomycin functions by disrupting key oncogenic signaling pathways including Wnt/β-catenin, Notch, Hedgehog, and Akt, reducing CSC viability and enhancing sensitivity to standard chemotherapeutics. Mechanistically, it induces apoptosis, autophagy, and

June 26, 2025 No Comments

Increased ROS Generation and p53 Activation in Alpha-Lipoic Acid-Induced Apoptosis of Hepatoma Cells

This 2006 study investigates the pro-apoptotic effects of alpha-lipoic acid (α-LA) on hepatoma cell lines FaO and HepG2. Treatment with α-LA resulted in inhibited cell proliferation, decreased cyclin A expression, and increased levels of cell cycle inhibitors p21^Cip1 and p27^Kip1, leading to cell cycle arrest. Apoptosis was characterized by DNA

June 26, 2025 No Comments

Antileukemic activity and cellular effects of the antimalarial agent artesunate in acute myeloid leukemia

This study investigates the antileukemic activity of artesunate, an antimalarial drug, in acute myeloid leukemia (AML). The results show that artesunate effectively inhibits AML cell proliferation and induces apoptosis through reactive oxygen species (ROS) generation and mitochondrial dysfunction. These findings suggest that artesunate may serve as a promising therapeutic agent

June 26, 2025 No Comments

Ascorbic Acid Induces Necrosis in Human Laryngeal Squamous Cell Carcinoma via ROS, PKC, and Calcium Signaling

This study investigates the effects of ascorbic acid (vitamin C) on human laryngeal squamous cell carcinoma (LSCC) cells, showing that it induces necrosis through the activation of reactive oxygen species (ROS), protein kinase C (PKC), and calcium signaling pathways. The findings suggest that ascorbic acid may serve as a potential

June 26, 2025 No Comments

The Sirtuins, Oxidative Stress and Aging: An Emerging Link

This review explores the role of sirtuins, a family of NAD⁺-dependent deacetylases, in modulating oxidative stress and aging. Sirtuins, particularly SIRT1 and SIRT3, enhance cellular resistance to oxidative damage by deacetylating key transcription factors and enzymes involved in antioxidant defense, such as FOXO proteins and SOD2. Caloric restriction activates sirtuins,

June 26, 2025 No Comments

Maintaining good hearing: calorie restriction, Sirt3, and glutathione

This review examines how calorie restriction (CR) can slow the progression of age-related hearing loss (AHL), a common aging condition linked to the degeneration of sensory hair cells, spiral ganglion neurons, and the stria vascularis in the cochlea. The study highlights mitochondrial Sirt3, a sirtuin protein, as a critical mediator

June 26, 2025 No Comments

Oxidative stress and mitochondrial dysfunction across broad-ranging pathologies: toward mitochondria-targeted clinical strategies

This systematic review examines the role of oxidative stress and mitochondrial dysfunction in a wide range of chronic diseases, including neurodegenerative disorders, cardiovascular disease, metabolic syndrome, cancer, and age-related conditions. The review underscores the damaging cycle of reactive oxygen species (ROS) and mitochondrial impairment, which drives cellular decline. It highlights

June 26, 2025 No Comments

Tag: ROS