The 2025 study "Glutamine Supplementation as a Novel Metabolic Therapeutic Strategy for LIG3-Dependent Chronic Intestinal Pseudo-Obstruction" explores glutamine as a therapeutic approach for treating chronic intestinal pseudo-obstruction (CIPO) caused by LIG3 mutations. The study finds that glutamine supplementation improves intestinal motility, reduces symptoms such as bloating and constipation, and enhances
