Well Referenced

Tag: Glutamine supplementation

Effects of glutamine supplements and radiochemotherapy on systemic immune and gut barrier function in patients with advanced esophageal cancer

This 1998 clinical trial evaluated the impact of oral glutamine supplementation (30 g/day for 28 days) on immune and gut barrier function in 13 patients with advanced esophageal cancer undergoing radiochemotherapy (5-fluorouracil and cisplatin with mediastinal irradiation). Compared to controls, the glutamine group maintained higher lymphocyte counts (1007 ± 151/mm³

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June 26, 2025 No Comments

A comprehensive insight into the effect of glutamine supplementation on metabolic variables in diabetes mellitus: a systematic review

The 2020 systematic review titled “A Comprehensive Insight into the Effect of Glutamine Supplementation on Metabolic Variables in Diabetes Mellitus” (PMID: 32983244) evaluated 19 studies, including clinical and animal research, to assess glutamine’s impact on glycemic control and metabolic health in individuals with diabetes. The review found that glutamine supplementation

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June 26, 2025 No Comments

Glutamine as an immunonutrient

The 2011 review article “Glutamine as an Immunonutrient” (PMID: 22028151) explores the role of glutamine, the most abundant amino acid in the human body, in maintaining immune function and supporting recovery under stress conditions such as illness, trauma, or surgery. Though not traditionally classified as essential, glutamine becomes conditionally essential

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June 26, 2025 No Comments

Glutamine supplementation

The 2011 review article “Glutamine Supplementation” (Annals of Intensive Care, https://doi.org/10.1186/2110-5820-1-25) evaluates the clinical significance of glutamine as a conditionally essential amino acid during critical illness, particularly in ICU patients receiving total parenteral nutrition (TPN). The review emphasizes that intravenous (IV) glutamine at 0.3–0.5 g/kg/day restores plasma levels, improves immune

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June 26, 2025 No Comments

Glutamine Supplementation as a Novel Metabolic Therapeutic Strategy for LIG3-Dependent Chronic Intestinal Pseudo-Obstruction

The 2025 study “Glutamine Supplementation as a Novel Metabolic Therapeutic Strategy for LIG3-Dependent Chronic Intestinal Pseudo-Obstruction” explores glutamine as a therapeutic approach for treating chronic intestinal pseudo-obstruction (CIPO) caused by LIG3 mutations. The study finds that glutamine supplementation improves intestinal motility, reduces symptoms such as bloating and constipation, and enhances

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June 26, 2025 No Comments

Oral glutamine is effective for preventing oxaliplatin-induced neuropathy in colorectal cancer patients

This randomized controlled trial investigated the effects of oral glutamine supplementation in preventing oxaliplatin-induced peripheral neuropathy among 86 metastatic colorectal cancer patients. Participants receiving glutamine (15 g twice daily for seven days every two weeks) experienced significantly lower rates of grade 3–4 neuropathy after four and six cycles (4.8% vs.

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June 26, 2025 No Comments

Prevention of Chemotherapy and Radiation Toxicity With Glutamine

This review article explores the use of glutamine supplementation to prevent chemotherapy and radiation-induced toxicities in cancer patients. Glutamine was found to reduce the severity and incidence of side effects such as mucositis, diarrhea (especially from irinotecan), peripheral neuropathy (notably from paclitaxel), hepatic veno-occlusive disease, and anthracycline-induced cardiotoxicity. It also

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June 26, 2025 No Comments

Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome

This randomized, double-blind, placebo-controlled trial titled “Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome” (PMID: 30108163), published in Gut, evaluated the efficacy of oral glutamine in patients with postinfectious diarrhea-predominant irritable bowel syndrome (IBS-D) and increased intestinal permeability. The study demonstrated that glutamine supplementation significantly improved

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June 26, 2025 No Comments

Review: The roles and functions of glutamine on intestinal health and performance of weaning pigs

This review article examines the role of glutamine supplementation in supporting intestinal health and improving performance in weaning pigs, a model used for studying gastrointestinal development in monogastric species. The findings highlight glutamine’s ability to enhance gut morphology (increased villus height and crypt depth), boost immune function, and support growth

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June 26, 2025 No Comments