This 2013 randomized, placebo-controlled crossover study investigated the effects of intranasal oxytocin (24 IU) on food intake and metabolic parameters in healthy men. Participants received oxytocin or placebo, and their food intake was assessed in both fasted and postprandial states. The study found that oxytocin administration significantly reduced snack consumption,
This study evaluated the anti-stress effects of Holixer™, a standardized extract of Ocimum tenuiflorum (Holy Basil), using in vivo models (swim endurance in mice and forced swim tests in rats) and in vitro HPA-axis assays. Results showed that Holixer™ significantly improved physical endurance, reduced stress-induced immobility, and normalized corticosterone levels.
This randomized, double-blind, placebo-controlled trial assessed the effects of Ginkgo biloba extract (EGb 761) on stress-induced blood pressure and cortisol responses in healthy young volunteers. The study found that EGb 761 significantly reduced blood pressure increases during stress without affecting heart rate. In males, it also suppressed afternoon cortisol responses
This randomized, double-blind, placebo-controlled trial assessed the effects of Shoden, an ashwagandha extract, on stress and anxiety in healthy adults with high stress levels. Over 60 days, both 60 mg and 120 mg doses of Shoden significantly reduced anxiety and stress, as measured by the Hamilton Anxiety Rating Scale (HAMA)
This study investigates the anti-stress effects of Ocimum sanctum (O. sanctum) in a chronic variable stress (CVS) model using rats. It found that O. sanctum administration increased body weight gain and reduced immobility time, indicating potential benefits in managing stress-related behaviors. In vitro assays revealed that O. sanctum and its
This study examined the physiological and immune responses to short-term cold-water immersion (CWI) in healthy young males. The immersion at 14°C for 10 minutes led to a stress response, with increased heart rate, muscle shivering, and elevated levels of epinephrine, norepinephrine, and cortisol. Cytokine analysis showed a delayed increase in
This study examined the relationship between anxiety levels and the secretion of cortisol and dehydroepiandrosterone sulfate (DHEAS) in response to stress. Researchers assessed 66 participants categorized into low, medium, and high anxiety groups, subjecting them to a 5-minute mental arithmetic stress test while measuring their cortisol and DHEAS levels. Results
The article titled “Association of humoral markers of inflammation and dehydroepiandrosterone sulfate or cortisol serum levels in patients with chronic inflammatory bowel disease,” published in the American Journal of Gastroenterology (1998), examined the relationship between inflammatory markers and serum levels of adrenal hormones (DHEAS and cortisol) in patients with chronic
The observational study titled “Effect of exogenous estrogen on serum pregnenolone, cortisol, and androgens in postmenopausal women” (Obstetrics & Gynecology, 1975, PMID: 163457) examined how estrogen therapy influences adrenal steroidogenesis in postmenopausal women. The study found that exogenous estrogen significantly increased serum levels of pregnenolone, cortisol, and androgens, suggesting that
A single-blind, placebo-controlled crossover study examined the effects of dehydroepiandrosterone (DHEA) administration on 24-hour plasma cortisol levels in healthy older adults. Participants received either a placebo or 200 mg of oral DHEA daily for 15 days. The study found that DHEA administration significantly reduced plasma cortisol concentrations, with a more
