Commentary on “Ascorbate kills breast cancer cells by rewiring metabolism via redox imbalance and energy crisis” by Ghanem et al.

This expert commentary by Barry Halliwell analyzes and contextualizes the findings from Ghanem et al., who reported that high-dose ascorbate (vitamin C) selectively induces death in breast cancer cells through redox imbalance and metabolic disruption. The mechanism involves increased oxidative stress, mitochondrial dysfunction, ATP depletion, and a shift in cellular