This 2006 meta-analysis assessed cancer incidence among female flight attendants by analyzing cohort studies from 1966 to 2005. The study found significantly increased risks for malignant melanoma (RR 2.13, 95% CI: 1.58–2.88) and breast cancer (RR 1.41, 95% CI: 1.22–1.62) compared to the general population. No significant excess risk was
This 2015 study analyzed breast cancer incidence among 6,093 former female U.S. flight attendants, focusing on potential occupational exposures such as cosmic radiation and circadian rhythm disruption. The findings revealed a 51% higher prevalence of breast cancer in flight attendants compared to the general population. While no direct exposure-response relationship
This 2020 study by Wang et al. analyzed data from the Long Island Breast Cancer Study Project to assess the association between menopausal hormone therapy (MHT) use and long-term mortality outcomes. Among women with breast cancer, ever-users of MHT had a 23% lower risk of all-cause mortality (HR=0.77), a 31%
This 2017 article by Lauren Vogel in the Canadian Medical Association Journal critiques the generalization of the Women’s Health Initiative (WHI) trial results, which primarily involved women over 60, to younger women considering hormone replacement therapy (HRT). The WHI findings, indicating increased risks of breast cancer, heart disease, and stroke
This 2022 prospective trial assessed the diagnostic performance of ultrasound versus mammography in 2,737 Chinese women with suspected breast lesions. All participants underwent both imaging modalities followed by biopsy confirmation. Ultrasound demonstrated a significantly higher sensitivity (95.7%) compared to mammography (78.9%) for detecting breast cancer (p < 0.001). However, ultrasound
This 2007 study by Fournier et al. analyzed data from the French E3N cohort to assess breast cancer risk associated with various hormone replacement therapies (HRTs) in postmenopausal women. Over an average follow-up of 8.1 years involving 80,377 women, 2,354 cases of invasive breast cancer were identified. The study found
This 2020 population-based cohort study evaluated breast cancer mortality trends in Victoria, Australia, over a 27-year period, analyzing the relative contributions of mammographic screening and adjuvant therapy. Using data from the Victorian Cancer Registry and BreastScreen Victoria, the researchers applied age-period-cohort modeling to isolate the effects of each intervention. Results
This review examines the potential association between sodium-glucose cotransporter 2 (SGLT2) inhibitors and cancer risk. Early clinical trials of dapagliflozin indicated an imbalance in reported cases of breast and bladder cancer, raising safety concerns. However, these findings lacked statistical significance and may be attributed to early cancer detection rather than
This study investigates the effects of both acute and chronic cadmium (Cd) exposure on E-cadherin degradation in MCF7 breast cancer cells. The researchers found that Cd exposure leads to the degradation of E-cadherin via the ubiquitination pathway, resulting in reduced E-cadherin/β-catenin complexes and increased nuclear translocation of β-catenin. This translocation
This 2019 systematic review and meta-analysis assessed the diagnostic performance of ultrasound (US) as a primary tool for early detection of breast cancer globally. Analyzing data from 22 studies encompassing 16,366 women, the study found that US had a pooled sensitivity of 80% and specificity of 88% for breast cancer
