Combination of High-Dose Parenteral Ascorbate (Vitamin C) and Alpha-Lipoic Acid Failed to Enhance Tumor-Inhibitory Effect But Increased Toxicity in Preclinical Cancer Models

This preclinical study investigated the combined effects of high-dose intravenous vitamin C (ascorbate, Asc) and alpha-lipoic acid (ALA) on six human cancer cell lines and a mouse model of metastatic breast cancer. While high-dose Asc alone demonstrated tumor-inhibitory effects without toxicity, ALA did not inhibit tumor growth and instead increased