This systematic review examines the role of chelation therapy in the treatment of mercury, lead, and copper intoxications, highlighting newer chelating agents such as meso-2,3-dimercaptosuccinic acid (DMSA) and 2,3-dimercapto-propanesulphonate (DMPS), which have a safer profile compared to older agents like dimercaptopropanol (BAL). The review also discusses the use of D-penicillamine
