Well Referenced

Tag: heavy metal poisoning

Severe iatrogenic bismuth poisoning with bismuth iodoform paraffin paste treated with DMPS chelation

This case report describes a 67-year-old male who suffered from severe iatrogenic bismuth toxicity due to prolonged use of bismuth iodoform paraffin paste (BIPP) for postoperative wound packing following pelvic tumor resection. The patient presented with neuropsychiatric symptoms, and investigations revealed critically elevated bismuth levels in blood (340 µg/L) and

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June 26, 2025 No Comments

Cadmium Toxicity and Treatment

This comprehensive review examines cadmium, a highly toxic heavy metal with widespread environmental and occupational exposure. Cadmium accumulates in the body, particularly in the kidneys and liver, leading to multi-organ damage. Chronic exposure is associated with renal dysfunction, bone demineralization, and increased cancer risk. The primary sources of cadmium exposure

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June 26, 2025 No Comments

Metal chelators and neurotoxicity: lead, mercury, and arsenic

This review examines the use of metal chelators, including DMSA, DMPS, and CaEDTA, in treating lead, mercury, and arsenic poisoning, with a focus on their efficacy, safety, and potential combination therapies. The study highlights that DMSA is a safer alternative to CaEDTA for moderate lead poisoning and suggests that DMSA

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June 26, 2025 No Comments

Mobilization of heavy metals by newer, therapeutically useful chelating agents

This review examines the effectiveness and safety of four chelating agents—DMSA, DMPS, CaNa₂EDTA, and BAL—for treating heavy metal poisoning, particularly lead, mercury, and arsenic intoxication. The study highlights that DMSA and DMPS are safer and more effective alternatives to traditional chelators like CaNa₂EDTA and BAL, with DMSA primarily used for

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June 26, 2025 No Comments

MY APPROACH to the use of chelation therapy

This expert opinion article by Dr. Gervasio A. Lamas explores the role of chelation therapy in cardiovascular medicine, discussing its historical use for heavy metal poisoning and its controversial application in treating cardiovascular diseases. The author highlights the hypothesis that chelation therapy may reduce atherosclerosis by removing metal ions that

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June 26, 2025 No Comments

Pediatric fatality secondary to EDTA chelation

This case report details the fatal outcome of a five-year-old autistic child who suffered cardiac arrest due to severe hypocalcemia after mistakenly receiving edetate disodium (EDTA) instead of the safer edetate calcium disodium during chelation therapy. The report highlights the risks of improper chelating agent selection, particularly in pediatric patients,

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June 26, 2025 No Comments

Chelation in metal intoxication–Principles and paradigms

This review article discusses the role of chelation therapy in treating metal intoxication, focusing on the advancements and use of newer, less toxic chelating agents like DMSA and DMPS, which are effective for treating heavy metal poisoning and available in oral form. It highlights DMSA’s potency in treating copper overload

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June 26, 2025 No Comments

Chelation therapy in intoxications with mercury, lead and copper

This systematic review examines the role of chelation therapy in the treatment of mercury, lead, and copper intoxications, highlighting newer chelating agents such as meso-2,3-dimercaptosuccinic acid (DMSA) and 2,3-dimercapto-propanesulphonate (DMPS), which have a safer profile compared to older agents like dimercaptopropanol (BAL). The review also discusses the use of D-penicillamine

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June 26, 2025 No Comments