Well Referenced

Tag: DMSA

Efficacy of DMSA Therapy in a Sample of Arab Children with Autistic Spectrum Disorder

This clinical study evaluated the use of dimercaptosuccinic acid (DMSA) in Arab children diagnosed with Autism Spectrum Disorder (ASD) to explore possible benefits related to heavy metal detoxification. The study involved a structured chelation protocol and assessed behavioral changes post-treatment. Results showed statistically significant improvements in communication, social interaction, and

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June 26, 2025 No Comments

A Review on Coordination Properties of Thiol-Containing Chelating Agents Towards Mercury, Cadmium, and Lead

This review analyzes the coordination behavior and therapeutic potential of thiol-based chelators—DMSA, DMPS, BAL, and α-lipoic acid—against toxic metals mercury (Hg), cadmium (Cd), and lead (Pb). It outlines how these metals interact preferentially with sulfur-containing ligands due to their classification as soft or borderline acids. DMSA is noted for its

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June 26, 2025 No Comments

Dimercaptosuccinic acid (succimer; DMSA) in inorganic lead poisoning

This review examines the use of dimercaptosuccinic acid (DMSA or succimer) in treating inorganic lead poisoning. DMSA is an orally administered chelating agent that effectively increases urinary excretion of lead and lowers blood lead levels. It is well absorbed, binds to plasma proteins, and is excreted primarily via the kidneys.

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June 26, 2025 No Comments

Chelation: harnessing and enhancing heavy metal detoxification–a review

This 2013 review by Margaret E. Sears examines the role of chelation in detoxifying heavy metals such as arsenic, cadmium, lead, and mercury, which are prevalent environmental toxins contributing to chronic diseases. The paper discusses both natural chelators like glutathione and metallothionein, and pharmaceutical agents such as EDTA, DMSA, and

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June 26, 2025 No Comments

Arsenic Toxicity: Molecular Targets and Therapeutic Agents

This in-depth review outlines the molecular pathways affected by arsenic toxicity and surveys both conventional and emerging therapeutic strategies. Arsenic exposure—primarily via contaminated water and food—induces oxidative stress, mitochondrial dysfunction, epigenetic alterations, and DNA damage, contributing to carcinogenesis, cardiovascular disorders, and neurotoxicity. The review highlights the use of chelating agents

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June 26, 2025 No Comments

Recommendations for Provoked Challenge Urine Testing

This critical review assesses the clinical validity of provoked challenge urine testing for detecting heavy metal exposure. The authors outline key issues with the test, including lack of standardization in chelator type, dosing, and urine collection timing. It highlights how comparisons are often made to unvalidated reference ranges, resulting in

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June 26, 2025 No Comments

Mercury binding to the chelation therapy agents DMSA and DMPS and the rational design of custom chelators for mercury

This study investigates the efficacy of two commonly used chelation therapy agents, meso-2,3-dimercaptosuccinic acid (DMSA) and 2,3-dimercaptopropane-1-sulfonic acid (DMPS), in binding mercuric ions (Hg²⁺). Using mercury L(III)-edge X-ray absorption spectroscopy and density functional theory calculations, researchers found that neither DMSA nor DMPS forms true chelate complexes with Hg²⁺, which may

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June 26, 2025 No Comments