This 2011 randomized, double-blind, placebo-controlled crossover study examined the effects of 150 mg/day resveratrol supplementation over 30 days in 11 healthy obese men. Resveratrol significantly reduced sleeping and resting metabolic rates. In skeletal muscle, it activated AMPK, increased SIRT1 and PGC-1α protein levels, and enhanced mitochondrial respiration on fatty acid-derived
