Well Referenced

Tag: AMPK activation

Metabolaid® Combination of Lemon Verbena and Hibiscus Flower Extract Prevents High-Fat Diet-Induced Obesity through AMP-Activated Protein Kinase Activation

This 2018 preclinical study investigated the effects of Metabolaid®, a combination of lemon verbena and hibiscus flower extracts, on obesity and metabolic parameters in high-fat diet-induced obese mice. The treatment led to significant reductions in body weight, white adipose tissue, and liver weight. Improvements were observed in serum and hepatic

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June 26, 2025 No Comments

Traditional Chinese Medicine in Treatment of Metabolic Syndrome

This comprehensive review explores the role of Traditional Chinese Medicine (TCM) in managing metabolic syndrome (MetS). It introduces TCM principles and evaluates 25 traditional Chinese herbs for their potential therapeutic effects on MetS components, including obesity, insulin resistance, dyslipidemia, and hypertension. Notably, ginseng (Panax ginseng and Panax quinquefolium) exhibits anti-hyperglycemic,

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June 26, 2025 No Comments

Resveratrol as a Calorie Restriction Mimetic: Therapeutic Implications

This review examines resveratrol’s potential as a calorie restriction (CR) mimetic, highlighting its effects on aging-related diseases such as type 2 diabetes, cardiovascular diseases, and cancer in preclinical models. Resveratrol’s mechanism involves the inhibition of cAMP phosphodiesterases (PDEs), particularly PDE4, leading to increased cAMP levels and activation of downstream pathways

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June 26, 2025 No Comments

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

This 2011 randomized, double-blind, placebo-controlled crossover study examined the effects of 150 mg/day resveratrol supplementation over 30 days in 11 healthy obese men. Resveratrol significantly reduced sleeping and resting metabolic rates. In skeletal muscle, it activated AMPK, increased SIRT1 and PGC-1α protein levels, and enhanced mitochondrial respiration on fatty acid-derived

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June 26, 2025 No Comments

Reversing the Warburg effect as a treatment for glioblastoma

This study explores the potential of methylene blue (MB) to reverse the Warburg effect in glioblastoma multiforme (GBM) cells. MB treatment increased oxygen consumption and decreased lactate production, indicating a shift from glycolysis to oxidative phosphorylation. MB inhibited GBM cell proliferation and induced S-phase cell cycle arrest. Mechanistically, MB activated

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June 26, 2025 No Comments

Combined activation of the energy and cellular-defense pathways may explain the potent anti-senescence activity of methylene blue

This study investigates the anti-senescence effects of methylene blue (MB) in human fibroblast cells. MB treatment transiently increased the NAD/NADH ratio, leading to activation of AMPK, which subsequently induced PGC1α and SURF1, promoting mitochondrial and complex IV biogenesis. MB also activated the Keap1/Nrf2 pathway, enhancing cellular defense mechanisms. These combined

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June 26, 2025 No Comments

Metformin and Cancer, an Ambiguanidous Relationship

This 2022 review explores the complex role of metformin, a widely used antidiabetic agent, in cancer therapy. Metformin activates the AMPK pathway and inhibits mitochondrial complex I, leading to reduced ATP production and downstream inhibition of mTOR and PI3K/AKT signaling pathways. These actions result in decreased tumor cell proliferation and

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June 26, 2025 No Comments

Metformin: A Hopeful Promise in Aging Research

This 2016 review highlights metformin’s potential as a geroprotective agent beyond its established use in type 2 diabetes management. The authors discuss metformin’s mechanisms, including activation of AMPK, inhibition of mTOR signaling, reduction of oxidative stress, and modulation of inflammatory responses. These actions collectively contribute to improved metabolic health and

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June 26, 2025 No Comments

Berberine Phospholipid Is an Effective Insulin Sensitizer and Improves Metabolic and Hormonal Disorders in Women with Polycystic Ovary Syndrome: A One-Group Pretest-Post-Test Explanatory Study

The study “Berberine Phospholipid Is an Effective Insulin Sensitizer and Improves Metabolic and Hormonal Disorders in Women with Polycystic Ovary Syndrome,” published in Nutrients (2021), investigated the effects of berberine phospholipid supplementation on insulin sensitivity and metabolic and hormonal disturbances in women with polycystic ovary syndrome (PCOS). The results indicated

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June 26, 2025 No Comments