Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots

Methylene blue (MB) demonstrates potential as a therapeutic agent by enhancing mitochondrial function and altering energy metabolism. Acting as an alternative electron carrier, MB bypasses mitochondrial dysfunction, increasing oxygen consumption, decreasing glycolysis, and improving glucose uptake. In rodent models, MB enhanced regional cerebral blood flow and provided neuroprotection, while in