This 2020 retrospective observational study assessed the impact of high-dose intravenous vitamin C (IVC) on the neutrophil-lymphocyte ratio (NLR) in 424 breast cancer patients undergoing postoperative radiotherapy. Patients were divided into three groups: control (no IVC), low-dose IVC (1 g/kg). NLR, a marker of systemic inflammation linked to cancer prognosis,