This 2018 prospective case series study evaluated the incidence of renal stones in 157 adult patients undergoing intravenous vitamin C (IVC) therapy over a 12-month period. Patients received varying doses of IVC, with follow-up assessments at enrollment, 6 months, and 12 months. Renal function was monitored through serum creatinine and
This 1976 study by Cameron and Pauling evaluated the effect of high-dose vitamin C (10 g/day, initially IV then oral) on survival in 100 terminal cancer patients compared to 1,000 matched controls. Results showed significantly prolonged survival in the ascorbate group, with a mean survival extension of around 300 days
This 2020 retrospective observational study assessed the impact of high-dose intravenous vitamin C (IVC) on the neutrophil-lymphocyte ratio (NLR) in 424 breast cancer patients undergoing postoperative radiotherapy. Patients were divided into three groups: control (no IVC), low-dose IVC (1 g/kg). NLR, a marker of systemic inflammation linked to cancer prognosis,
This 2021 narrative review examines the use of high-dose intravenous vitamin C (IVC) in advanced-stage cancer patients. While preclinical studies demonstrate that pharmacologic concentrations of ascorbate can exert cytotoxic effects on malignant cells and enhance the efficacy of chemotherapy, clinical evidence in humans remains limited. Some studies suggest that IVC
This 2015 case report details a 74-year-old woman with hepatocellular carcinoma (HCC) who experienced regression of multiple pulmonary metastases following intravenous high-dose vitamin C therapy. After initial transarterial chemoembolization (TACE), she developed recurrent HCC with lung metastases and declined further conventional treatment. She received 70 g of intravenous vitamin C
This phase 3 randomized study evaluates the efficacy and safety of high-dose vitamin C in combination with FOLFOX ± bevacizumab in patients with unresectable, untreated metastatic colorectal cancer (CRC). The results suggest that the addition of vitamin C to standard chemotherapy may improve clinical outcomes by enhancing treatment response. However,
