This 2025 review article published in Current Medicinal Chemistry (DOI: 10.2174/0109298673300496240416114827, PMID: 38644711) highlights the broad therapeutic potential of alpha-lipoic acid (ALA), focusing on its antioxidant and anti-aging properties across a wide range of chronic and degenerative conditions. ALA modulates key biological pathways including NF-κB, Nrf2, and AMPK, helping to