Hormone replacement therapy, menopausal age and lifestyle variables are associated with better cognitive performance at follow-up but not cognition over time in older-adult women irrespective of APOE4 carrier status and co-morbidities

This observational study examined the link between hormone replacement therapy (HRT) use and the risk of breast cancer in postmenopausal women. It found that oral opposed estrogens (estrogen with progesterone) significantly increased the risk of breast cancer, with the risk rising with each additional prescription. In contrast, transdermal opposed estrogens,