vasodilation Archives - Well Referenced

Peripheral and Central Effects of Melatonin on Blood Pressure Regulation

This 2014 review examines melatonin’s role in blood pressure regulation through both peripheral and central mechanisms. Peripherally, melatonin interacts with MT1 and MT2 receptors, leading to vasodilation, and exerts antioxidant effects by scavenging reactive oxygen species and enhancing mitochondrial efficiency. Centrally, it modulates autonomic balance by reducing sympathetic activity and

June 26, 2025 No Comments

Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction

This single-blind study evaluated the efficacy of oral L-citrulline supplementation in 24 men with mild erectile dysfunction (ED), characterized by an erection hardness score (EHS) of 3. Participants received a placebo for one month, followed by 1.5 g/day of L-citrulline for another month. Results showed that 50% of the men

June 26, 2025 No Comments

Oral adenosine-5′-triphosphate (ATP) administration increases blood flow following exercise in animals and humans

This study evaluated the effects of oral ATP supplementation on exercise-induced blood flow in both animal and human models. In rats, various doses of ATP (100–1,600 mg human equivalent) were administered prior to electrically stimulated leg exercise. The 1,000 mg dose notably enhanced femoral artery blood flow during and post-exercise,

June 26, 2025 No Comments

Light-Induced Nitric Oxide Release in the Skin Beyond UVA and Blue Light: Red & Near-Infrared Wavelengths

This 2021 review explores the role of red and near-infrared (NIR) light in stimulating nitric oxide (NO) release from the skin, expanding upon prior focus on UVA and blue light. The study highlights mechanisms including photolysis of nitrosated species and potential activation of nitric oxide synthase (NOS), even at non-damaging

June 26, 2025 No Comments

Magnesium inhibits norepinephrine release by blocking N-type calcium channels at peripheral sympathetic nerve endings

This in vitro and animal study explored the role of magnesium in regulating blood pressure by examining its effect on norepinephrine release from sympathetic nerve endings. Using hypertensive and normotensive rat models, as well as cultured PC12 cells, researchers found that magnesium significantly inhibited norepinephrine release—reducing it by 51% in

June 26, 2025 No Comments

L-arginine as a nutritional prophylaxis against vascular endothelial dysfunction with aging

This review explores the potential benefits of L-arginine supplementation in mitigating age-related vascular endothelial dysfunction. L-arginine plays a crucial role in nitrogen detoxification, immune function, growth hormone secretion, and insulin regulation. It serves as a substrate for nitric oxide synthase, promoting nitric oxide (NO) production, which enhances vasodilation and vascular

June 26, 2025 No Comments

Acute effects of Nitrosigine® and citrulline malate on vasodilation in young adults

This randomized controlled trial examined the effects of Nitrosigine® (arginine and silicon) and citrulline malate (CM) on endothelial-dependent vasodilation in 24 healthy, physically active adults. Participants consumed either 1.5 g of Nitrosigine®, 8 g of CM, or a placebo, with flow-mediated dilation (FMD) measured before and 60 minutes post-ingestion. Both

June 26, 2025 No Comments

Endogenous flux of nitric oxide: Citrulline is preferred to Arginine

The article “Endogenous flux of nitric oxide: Citrulline is preferred to Arginine” (Acta Physiol (Oxf), 2021, PMID: 33089645) reviews the comparative effectiveness of citrulline versus arginine supplementation in enhancing nitric oxide (NO) production. Due to arginine’s significant first-pass metabolism in the splanchnic region, its systemic availability is limited, making citrulline

June 26, 2025 No Comments

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