The article "Endogenous flux of nitric oxide: Citrulline is preferred to Arginine" (Acta Physiol (Oxf), 2021, PMID: 33089645) reviews the comparative effectiveness of citrulline versus arginine supplementation in enhancing nitric oxide (NO) production. Due to arginine's significant first-pass metabolism in the splanchnic region, its systemic availability is limited, making citrulline
