Well Referenced

Tag: testosterone

Effects of subdermal implants of estradiol and testosterone on the endometrium of postmenopausal women

This 2007 retrospective study evaluated the endometrial effects of combined estradiol and testosterone subdermal implants in 258 postmenopausal women over two years. Endometrial thickness was monitored via ultrasonography, and hysteroscopic biopsies were performed in cases of thickening (>5 mm). Among 44 women with endometrial thickening, histological analysis revealed endometrial polyps

Read More »
June 26, 2025 No Comments

Hormonal therapy with estradiol and testosterone implants: bone protection?

This 2011 prospective cohort study assessed the impact of combined estradiol and testosterone implants on bone mineral density (BMD) in postmenopausal women. Sixty-one participants were divided into two groups: 34 women received hormone implants, while 27 did not undergo hormonal therapy. Over one year, the implant group maintained or slightly

Read More »
June 26, 2025 No Comments

Hyperprolactinemia and sexual function in men: a short review

This 2003 review examines the impact of hyperprolactinemia (HPRL) on male sexual function. HPRL is associated with decreased libido, erectile dysfunction, and ejaculatory disorders. While traditionally attributed to reduced testosterone levels, evidence suggests that prolactin may also exert direct effects on central neurotransmitter systems, influencing sexual function independently of testosterone.

Read More »
June 26, 2025 No Comments

The Impact of Luteinizing Hormone and Testosterone on Beta Amyloid (Aβ) Accumulation: Animal and Human Clinical Studies

This 2015 review explores the roles of luteinizing hormone (LH) and testosterone in modulating beta-amyloid (Aβ) accumulation, a hallmark of Alzheimer’s disease (AD). The authors discuss evidence from animal models and human studies indicating that decreased testosterone and increased LH levels are associated with elevated cerebral Aβ deposition. Mechanistically, testosterone

Read More »
June 26, 2025 No Comments

The Role of Anabolic Hormones for Wound Healing in Catabolic States

This comprehensive review examines the interplay between anabolic hormones, nutrition, and wound healing, particularly in catabolic states such as trauma, burns, and chronic illness. It highlights how deficiencies in key anabolic hormones—human growth hormone (HGH), insulin-like growth factor-1 (IGF-1), insulin, and testosterone—impair protein synthesis and lean body mass maintenance, leading

Read More »
June 26, 2025 No Comments

Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men

This randomized, double-blind, placebo-controlled trial investigated the distinct roles of testosterone and estradiol in regulating body composition, muscle strength, and sexual function in men. Healthy men aged 20–50 underwent pharmacological suppression of endogenous gonadal steroids and received varying doses of testosterone gel, with or without an aromatase inhibitor to block

Read More »
June 26, 2025 No Comments

Effect of Lepidium meyenii (MACA) on Sexual Desire and Its Absent Relationship with Serum Testosterone Levels in Adult Healthy Men

This 12-week double-blind, placebo-controlled, randomized trial investigated the effects of gelatinized maca (Lepidium meyenii) on sexual desire and hormone levels in 57 healthy men aged 21–56. Participants received either 1,500 mg or 3,000 mg of maca daily or a placebo. Self-perception of sexual desire was assessed at 4, 8, and

Read More »
June 26, 2025 No Comments

Effect of a Multi-Ingredient Based Food Supplement on Sexual Function in Women with Low Sexual Desire

This exploratory, prospective, non-controlled observational study assessed the efficacy of Libicare®, a multi-ingredient food supplement, in improving sexual function among 29 postmenopausal women aged 45–65 with low sexual desire (FSFI < 25.83). Participants consumed two tablets daily for two months. Libicare® contains extracts of Trigonella foenum-graecum, Turnera diffusa, Tribulus terrestris,

Read More »
June 26, 2025 No Comments

Influence of a Specialized Trigonella foenum-graecum Seed Extract (Libifem), on Testosterone, Estradiol and Sexual Function in Healthy Menstruating Women, a Randomised Placebo Controlled Study

This double-blind, randomized, placebo-controlled study evaluated the effects of a standardized Trigonella foenum-graecum (fenugreek) seed extract (Libifem) on sex hormones and sexual function in 80 healthy menstruating women aged 20–49 years with self-reported low sexual desire. Participants received 600 mg/day of Libifem or placebo over two menstrual cycles. Outcomes included

Read More »
June 26, 2025 No Comments

Hungry runners – low energy availability in male endurance athletes and its impact on performance and testosterone: mini-review

This mini-review examines the impact of low energy availability (LEA) on male endurance athletes, highlighting its association with decreased testosterone levels, reduced bone density, and suppressed resting metabolic rate. LEA, resulting from insufficient energy intake relative to expenditure, can impair recovery, adaptation, and performance. The review discusses the prevalence of

Read More »
June 26, 2025 No Comments