This in vitro study investigated the potential DNA-damaging effects of visible red light (RL) exposure on human dermal fibroblasts (HDFs), given its growing use in dermatology for acne, psoriasis, and wound healing. The study found that RL at fluences of 320 J/cm², 640 J/cm², and 1280 J/cm² (wavelength 633 ± 6 nm) did
This review explores the role of oxidative nucleic acid damage biomarkers, specifically 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoG), in disease detection and drug development. Elevated levels of these biomarkers, found at 1.3 to 5 times higher in patients than controls, have been linked to various diseases, including cancer, neurodegenerative disorders, and
This review explores the relationship between oxidative DNA damage and cancer risk in humans, highlighting how reactive oxygen species (ROS) contribute to DNA lesions that may lead to mutations and carcinogenesis. It discusses the body’s defense mechanisms against oxidative stress and the potential role of antioxidants in cancer prevention. The
This observational study investigated the relationship between lifestyle factors and oxidative stress biomarkers in 135 healthy Japanese adults aged 20 to 69 years. The findings showed that smokers had significantly higher urinary 8-hydroxydeoxyguanosine (8-OHdG) levels (p < 0.05), indicating increased oxidative DNA damage, while individuals who engaged in regular physical
This observational study examined the impact of active and passive smoking on oxidative DNA damage by measuring 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) levels in leukocyte DNA. Findings revealed that active smokers exhibited significantly higher oxidative DNA damage compared to non-smokers, while passive smokers also had elevated levels, though to a lesser extent. Other
This article explores the effects of hyperbaric oxygen treatment (HBOT) on mitochondrial function and oxidative stress, highlighting its potential therapeutic benefits. Short-term HBOT can impair mitochondrial function and increase reactive oxygen species (ROS), while long-term treatment improves mitochondrial activity and reduces ROS levels through enhanced antioxidant defenses. The findings suggest
The article reviews the mechanisms and clinical efficacy of hyperbaric oxygen therapy (HBOT), particularly for treating diabetic wounds and radiation injuries. HBOT works by enhancing oxygen supply and generating reactive oxygen and nitrogen species that activate cell signaling pathways involved in wound healing and tissue regeneration. Clinical studies support its
A study published in Lasers in Medical Science (2019) investigated the effects of 808-nm diode laser photobiomodulation (PBM) on wound healing in human endothelial cells. The results showed that PBM increased the production of reactive oxygen species (ROS), which in turn stimulated mitochondrial oxidative phosphorylation, boosting ATP production and promoting
This systematic review evaluates the efficacy and safety of photodynamic therapy (PDT) for skin rejuvenation, analyzing its impact on fine wrinkles, skin roughness, and hyperpigmentation. The findings indicate that PDT significantly improves skin texture, with moderate effects on hyperpigmentation, and is generally well-tolerated with transient erythema and edema as the
This in vitro and animal study investigated the effects of hyperbaric oxygen therapy (HBOT) on oxidative stress, inflammation, and angiogenesis, processes essential for tissue repair and regeneration. The findings showed that HBOT modulates oxidative stress and inflammatory responses while enhancing angiogenesis, suggesting potential therapeutic applications for wound healing, ischemic tissue
