Well Referenced

Tag: rat model

Dose-related neuroprotective versus neurodamaging effects of estrogens in rat cerebral ischemia: a systematic analysis

This 2009 systematic analysis reviewed 66 studies on estrogen’s effects in rat models of cerebral ischemia. The findings revealed that estrogen’s impact is dose-dependent: low doses administered via injections or silastic capsules exhibited neuroprotective effects, whereas high doses delivered through slow-release pellets were associated with increased ischemic damage. The study

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June 26, 2025 No Comments

Muscle cramps and magnesium deficiency: case reports

This 1996 animal study published in Archives of Toxicology examined the cardioprotective effects of magnesium sulfate in rats exposed to acute carbon monoxide (CO) poisoning. Rats treated with magnesium (270 mg/kg intraperitoneally) prior to CO exposure showed significantly less myocardial injury—such as reduced necrosis and interstitial hemorrhage—compared to untreated rats.

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June 26, 2025 No Comments

Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats

This study examined the effects of resveratrol in rats exposed to chronic unpredictable mild stress (CUMS), a model for depression. Resveratrol administration significantly reversed depressive-like behaviors, normalized serum corticosterone levels, and restored brain-derived neurotrophic factor (BDNF) expression in the hippocampus. These findings suggest that resveratrol may counteract stress-induced depression by

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June 26, 2025 No Comments

Α‑lipoic acid protects against cerebral ischemia/reperfusion-induced injury in rats

This 2015 study published in Molecular Medicine Reports (DOI: 10.3892/mmr.2015.3170, PMID: 25572614) explored the neuroprotective effects of alpha-lipoic acid (ALA) in a rat model of cerebral ischemia/reperfusion (I/R) injury. The results showed that ALA treatment significantly reduced infarct size, improved neurological deficits, and decreased oxidative stress markers, including malondialdehyde (MDA)

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June 26, 2025 No Comments

Protective effects of resveratrol on small intestines against intestinal ischemia-reperfusion injury in rats

This animal study investigated the protective role of resveratrol against intestinal ischemia-reperfusion (I/R) injury in rats, demonstrating significant reductions in liver enzyme levels, oxidative stress markers, and intestinal tissue damage. Resveratrol enhanced antioxidant capacity and reduced oxidative damage, suggesting its potential therapeutic application in clinical scenarios involving compromised intestinal blood

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June 26, 2025 No Comments

Methylene blue stimulates substrate-level phosphorylation catalysed by succinyl-CoA ligase in the citric acid cycle

This study investigated the effects of methylene blue on memory impairment in a rat model of Alzheimer’s disease (AD), focusing on its impact on cytochrome c oxidase (CCO) activity and mitochondrial function. The study found that methylene blue significantly improved spatial memory and increased CCO activity, suggesting enhanced mitochondrial function,

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June 26, 2025 No Comments

Methylene blue alleviates endothelial dysfunction and reduces oxidative stress in aortas from diabetic rats

This study investigated the effects of methylene blue (MB) on endothelial dysfunction and oxidative stress in diabetic rats. Streptozotocin-induced diabetes led to increased vascular contractility, reduced endothelial-dependent relaxation, and heightened oxidative stress, indicated by elevated hydrogen peroxide (H₂O₂) levels. Treatment with MB at a dose of 0.1 μM for 30

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June 26, 2025 No Comments

Methylene Blue Analogues with Marginal Monoamine Oxidase Inhibition Retain Antidepressant-like Activity

This study investigated five newly synthesized methylene blue (MB) analogues with low monoamine oxidase A (MAO-A) inhibitory activity to assess their antidepressant-like effects. In rats, these analogues exhibited significant antidepressant effects in the forced swim test (FST), similar to imipramine and MB, without affecting locomotor activity. Their IC₅₀ values for

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June 26, 2025 No Comments

Prostate cancer in men using testosterone supplementation

This study investigates the neuroprotective effects of progesterone (P4) in a rat model of ischemic stroke induced by transient middle cerebral artery occlusion (tMCAO). The results demonstrate that P4 significantly reduces infarct volume, preserves mitochondrial function, and decreases oxidative stress by inhibiting the mitochondrial permeability transition pore (mPTP). P4 also

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June 26, 2025 No Comments