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Tag: rat model

Comparison efficacy of ESWT and Wharton’s jelly mesenchymal stem cell in early osteoarthritis of rat knee

This 2019 preclinical study evaluated the therapeutic effects of extracorporeal shockwave therapy (ESWT), Wharton’s jelly-derived mesenchymal stem cells (WJMSCs), and their combination in a rat model of early knee osteoarthritis (KOA). All treatment modalities significantly improved cartilage integrity and subchondral bone remodeling, as evidenced by pathological assessments, micro-CT, and immunohistochemical

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June 26, 2025 No Comments

Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats

This 2019 preclinical study evaluated the therapeutic effects of BPC 157, a stable gastric pentadecapeptide, on spinal cord injury (SCI) in rats. Following laminectomy and compression injury at the L2–L3 level, rats received a single intraperitoneal injection of BPC 157 (2 or 200 μg/kg) or saline 10 minutes post-injury. BPC

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June 26, 2025 No Comments

Bowel adhesion and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine in rats

This 2020 preclinical study investigated the effects of BPC 157, a stable gastric pentadecapeptide, on bowel adhesion formation in rats following peritoneal injury. Rats underwent parietal peritoneum excision and received treatments including BPC 157, L-NAME (a nitric oxide synthase inhibitor), L-arginine (a nitric oxide precursor), or combinations thereof. BPC 157,

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June 26, 2025 No Comments

Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction

This 2017 preclinical study investigated the long-term effects of activating the central melanocortin system via intracerebroventricular infusion of melanotan II (MTII), a potent melanocortin receptor agonist, in adult F344BN rats. Over a 40-day period, MTII administration led to a persistent reduction in body mass and adiposity, despite food intake returning

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June 26, 2025 No Comments

The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat

This 2003 preclinical study assessed the neurotrophic and neuroprotective effects of melanotan-II, a potent melanocortin receptor agonist, in a rat model of sciatic nerve injury. Rats received subcutaneous injections of melanotan-II at doses of 2, 20, or 50 μg/kg every 48 hours following a sciatic nerve crush injury. The 20

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June 26, 2025 No Comments

Protective effect of methylene blue on TNBS-induced colitis in rats mediated through the modulation of inflammatory and apoptotic signalling pathways

This 2019 study investigated the therapeutic potential of methylene blue (MB) in a rat model of trinitrobenzene sulfonic acid (TNBS)-induced colitis, simulating ulcerative colitis. MB was administered intraperitoneally at doses of 1, 2, and 4 mg/kg, compared to a control group receiving sulfasalazine (500 mg/kg orally). MB treatment resulted in

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June 26, 2025 No Comments

Taurine ameliorates neurobehavioral, neurochemical and immunohistochemical changes in sporadic dementia of Alzheimer’s type (SDAT) caused by intracerebroventricular streptozotocin in rats

This preclinical study evaluated the neuroprotective effects of taurine in a rat model of sporadic Alzheimer’s disease induced by intracerebroventricular (ICV) injection of streptozotocin (STZ). Rats received a single bilateral ICV-STZ injection (3 mg/kg), leading to cognitive deficits, oxidative stress, and cholinergic dysfunction. Taurine was administered orally at 50 mg/kg

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June 26, 2025 No Comments

Calcitonin attenuates cartilage degeneration and nociception in an experimental rat model of osteoarthritis: role of TGF-β in chondrocytes

This 2016 study investigated the therapeutic effects of calcitonin on osteoarthritis (OA) using a rat model. Calcitonin administration resulted in reduced cartilage degradation and decreased pain sensitivity. The protective effects were associated with the modulation of Transforming Growth Factor-beta (TGF-β) signaling pathways in chondrocytes, suggesting that calcitonin may exert its

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June 26, 2025 No Comments