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Tag: Pulmonary Fibrosis

Therapeutic potential of products derived from mesenchymal stem/stromal cells in pulmonary disease

This 2018 review article explores the therapeutic potential of mesenchymal stem/stromal cell (MSC)-derived products, particularly conditioned media (CM) and extracellular vesicles (EVs), in treating pulmonary diseases. MSCs are known for their regenerative and immunomodulatory properties, which are largely mediated through their secretome. The review highlights preclinical studies demonstrating the efficacy

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June 26, 2025 No Comments

The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis

This 2018 review examines the role of the PI3K/AKT/mTOR pathway in the development and progression of pulmonary fibrosis, particularly idiopathic pulmonary fibrosis (IPF) and radiation-induced pulmonary fibrosis (RIPF). It outlines how mTOR dysregulation contributes to fibroblast proliferation, suppression of autophagy, chronic inflammation, and epithelial-mesenchymal transition (EMT), all of which drive

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June 26, 2025 No Comments

Nicotinamide Mononucleotide Ameliorates Senescence in Alveolar Epithelial Cells

This study investigates the effects of nicotinamide mononucleotide (NMN) on alveolar epithelial cell (AEC) senescence. NMN supplementation in aged C57BL/6 mice (8–10 months old) and in a bleomycin-induced pulmonary fibrosis model in young mice (6–8 weeks old) demonstrated significant mitigation of age-associated physiological decline in the lungs. In vitro, NMN

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June 26, 2025 No Comments