Well Referenced

Tag: postmenopausal women

Estrogen, menopause, and the aging brain: how basic neuroscience can inform hormone therapy in women

This article examines the role of estrogen in cognitive aging and the potential benefits of hormone therapy (HT) for postmenopausal women. The authors review basic neuroscience findings, clinical studies, and epidemiological data to explore how estrogen influences brain function, including its neuroprotective effects on synaptic plasticity and cognitive processes. While

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June 26, 2025 No Comments

Evaluation of the clinical relevance of benefits associated with transdermal testosterone treatment in postmenopausal women with hypoactive sexual desire disorder

This 2007 randomized controlled trial evaluated the effects of transdermal testosterone therapy in postmenopausal women diagnosed with hypoactive sexual desire disorder (HSDD). The study found that testosterone therapy significantly improved sexual desire and activity levels compared to placebo, with increases in satisfying sexual episodes and overall sexual function scores. Testosterone

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June 26, 2025 No Comments

Health related quality of life after combined hormone replacement therapy: randomised controlled trial

This randomized controlled trial investigated the effects of combined hormone replacement therapy (HRT) on health-related quality of life in postmenopausal women. The study found that, after one year of treatment, HRT significantly improved vasomotor symptoms, sexual functioning, and sleep quality compared to a placebo. Specifically, the incidence of hot flushes

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June 26, 2025 No Comments

Hormone replacement therapy and cardiovascular disease revisited

This article revisits the effects of hormone replacement therapy (HRT) on cardiovascular disease, particularly in postmenopausal women. It highlights the Women’s Health Initiative (WHI) study, which initially showed risks such as increased cardiovascular events and cancer, leading to the conclusion that HRT should be avoided. However, further analysis indicated no

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June 26, 2025 No Comments

Hormone replacement therapy in postmenopausal women

This article provides a comprehensive review of hormone replacement therapy (HRT) for postmenopausal women, discussing its use in alleviating menopausal symptoms, preventing osteoporosis, and its potential impact on cardiovascular health. It highlights that while HRT was initially viewed as beneficial for cardiovascular protection, studies like the Women’s Health Initiative have

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June 26, 2025 No Comments

Hormone replacement therapy, menopausal age and lifestyle variables are associated with better cognitive performance at follow-up but not cognition over time in older-adult women irrespective of APOE4 carrier status and co-morbidities

This observational study examined the link between hormone replacement therapy (HRT) use and the risk of breast cancer in postmenopausal women. It found that oral opposed estrogens (estrogen with progesterone) significantly increased the risk of breast cancer, with the risk rising with each additional prescription. In contrast, transdermal opposed estrogens,

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June 26, 2025 No Comments

Efficacy and safety of testosterone in the management of hypoactive sexual desire disorder in postmenopausal women

The study titled “Efficacy and safety of testosterone in the management of hypoactive sexual desire disorder in postmenopausal women” (Journal of Sexual Medicine, 2012, PMID: 22304681) reviews the effectiveness and safety of transdermal testosterone therapy for postmenopausal women with hypoactive sexual desire disorder (HSDD). The findings suggest that transdermal testosterone

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June 26, 2025 No Comments

Hypoactive sexual desire disorder in postmenopausal women

The study titled Hypoactive Sexual Desire Disorder in Postmenopausal Women explores the impact of declining sex hormone levels, particularly estrogens and androgens, on sexual desire in postmenopausal women. It highlights that while conventional hormone therapy (estrogens or estrogens with progestogens) can relieve vaginal atrophy and dyspareunia, it does not consistently

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June 26, 2025 No Comments