Well Referenced

Tag: postmenopausal women

Effect of postmenopausal hormones on inflammation-sensitive proteins: the Postmenopausal Estrogen/Progestin Interventions (PEPI) Study

This clinical trial investigated the effect of postmenopausal hormone therapy (HRT) on inflammation-sensitive proteins, which are known to predict cardiovascular disease outcomes. The study found that HRT significantly reduced these proteins, suggesting a potential mechanism for lowering cardiovascular risk in postmenopausal women. However, the effect was dependent on the type

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June 26, 2025 No Comments

Effects of estradiol with and without testosterone on body composition and relationships with lipids in postmenopausal women

This study evaluated the effects of estradiol with and without testosterone on body composition and lipids in postmenopausal women. Estradiol improved body fat distribution and reduced LDL cholesterol, while testosterone had no impact on LDL but decreased abdominal fat. Estradiol and testosterone also reduced total cholesterol. The therapy offers benefits

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June 26, 2025 No Comments

A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women

This systematic review assesses randomized controlled trials (RCTs) on the efficacy and safety of testosterone therapy for postmenopausal women with sexual dysfunction. Key findings suggest that testosterone improves sexual function and may increase bone mineral density and decrease HDL cholesterol. However, the long-term safety remains unclear. The article aims to

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June 26, 2025 No Comments

Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys

This study examined the effects of oral estradiol combined with either micronized progesterone or medroxyprogesterone acetate on breast cancer risk markers in postmenopausal monkeys. Results showed that estradiol with medroxyprogesterone acetate significantly increased breast epithelial proliferation and expression of proliferation markers (Ki67, cyclin B1) compared to placebo (P < 0.01),

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June 26, 2025 No Comments

Androgens and breast cancer risk

This article reviews the use of testosterone supplementation for libido enhancement in postmenopausal women, noting that while it provides benefits, there are concerns about its potential to increase breast cancer risk due to the conversion of testosterone into oestradiol. The article calls for more high-quality studies to assess long-term safety.

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June 26, 2025 No Comments

Effects of estrogen/androgen therapy on bone mineral density parameters

This review examines the effects of combined estrogen-androgen therapy on bone mineral density (BMD) in postmenopausal women, highlighting its potential to enhance bone health beyond estrogen-only treatments. Estrogen helps prevent bone resorption, while androgens may promote bone formation and muscle mass, contributing to skeletal integrity. The study suggests that this

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June 26, 2025 No Comments

Androgens in women before and after the menopause and post bilateral oophorectomy: clinical effects and indications for testosterone therapy

This systematic review examines testosterone therapy for postmenopausal women, particularly those who have undergone bilateral oophorectomy. It highlights clinical evidence showing that testosterone therapy improves sexual desire, lean body mass, and bone mineral density. The therapy could be a crucial addition to hormone replacement for women suffering from androgen deficiency.

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June 26, 2025 No Comments

Associations between markers of inflammation and physiological and pharmacological levels of circulating sex hormones in postmenopausal women

This study, published in Menopause in 2010 (PMID: 20632462), investigated the relationship between sex hormone levels and inflammatory markers in postmenopausal women, both undergoing hormone therapy and not. Findings indicate that while hormone therapy can reduce vascular inflammation, oral estradiol therapy raises C-reactive protein (CRP), a marker of generalized inflammation.

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June 26, 2025 No Comments

Breast cancer risk in postmenopausal women using testosterone in combination with hormone replacement therapy

This review article discusses the potential impact of combining testosterone with estrogen in hormone replacement therapy for postmenopausal women and its associated risks, including breast cancer. It emphasizes the need for careful evaluation when using testosterone therapy alongside estrogen, especially for women with low sexual desire disorder, highlighting the importance

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June 26, 2025 No Comments