Well Referenced

Tag: postmenopausal women

Breast cancer risk in postmenopausal women using testosterone in combination with hormone replacement therapy

This review article discusses the potential impact of combining testosterone with estrogen in hormone replacement therapy for postmenopausal women and its associated risks, including breast cancer. It emphasizes the need for careful evaluation when using testosterone therapy alongside estrogen, especially for women with low sexual desire disorder, highlighting the importance

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June 26, 2025 No Comments

Clinical review: The benefits and harms of systemic dehydroepiandrosterone (DHEA) in postmenopausal women with normal adrenal function: a systematic review and meta-analysis

The article analyzes the effects of DHEA therapy in postmenopausal women with normal adrenal function. It finds that DHEA may improve sexual function and mood but has no significant impact on bone density. The study also highlights the risks, including acne and facial hair, and emphasizes the need for further

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June 26, 2025 No Comments

Current perspectives on benefits and risks of hormone replacement therapy

The review article “Current Perspectives on Benefits and Risks of Hormone Replacement Therapy” (2001) examines the effects of hormone replacement therapy (HRT) on postmenopausal women’s health, highlighting potential benefits and risks. Findings suggest that HRT users experience a 34% reduction in colorectal cancer risk and a 20% to 60% reduction

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June 26, 2025 No Comments

Cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys

The study titled “Cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys” (Journal of Neuroscience, 2003, PMID: 12843274) is an observational study investigating the effects of cyclic estrogen replacement on cognitive abilities in aged female rhesus monkeys following ovariectomy. Results showed significant improvements in cognitive tasks related to

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June 26, 2025 No Comments

Differential effects of estrogen-androgen and estrogen-only therapy on vasomotor symptoms, gonadotropin secretion, and endogenous androgen bioavailability in postmenopausal women

This study examined the effects of estrogen-androgen and estrogen-only therapy on vasomotor symptoms, gonadotropin secretion, and endogenous androgen bioavailability in postmenopausal women. The randomized controlled trial included 93 participants who received different hormone therapy regimens over 12 weeks. Findings showed that lower-dose estrogen-androgen therapy effectively reduced menopausal symptoms compared to

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June 26, 2025 No Comments

Does Menopausal Hormone Therapy, Exercise, or Both Improve Pain and Function in Postmenopausal Women With Greater Trochanteric Pain Syndrome? A 2 × 2 Factorial Randomized Clinical Trial

This randomized controlled trial investigated the effects of menopausal hormone therapy (MHT), exercise, and their combination on pain and function in postmenopausal women with Greater Trochanteric Pain Syndrome (GTPS). Results showed that both MHT and placebo, when combined with either tendon-specific or sham exercise plus education, led to pain reduction

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June 26, 2025 No Comments

Effect of different hormonal replacement therapies on circulating allopregnanolone and dehydroepiandrosterone levels in postmenopausal women

This study, published in Gynecological Endocrinology in 2003 (PMID: 12724021), examined the effects of various hormone replacement therapy (HRT) regimens on neurosteroid levels in 186 postmenopausal women over 12 months. Results showed that all HRT preparations significantly increased allopregnanolone levels, a neurosteroid with sedative and anxiolytic properties, suggesting a potential

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June 26, 2025 No Comments

Effect of menopausal hormone therapy on components of the metabolic syndrome

This review explores the impact of menopause on metabolic dysfunction and the role of menopausal hormone therapy (MHT) in mitigating components of metabolic syndrome (MetS), including visceral obesity, dyslipidemia, type 2 diabetes (T2D), and hypertension (HTN). MHT has been shown to improve body composition, lipid profiles, insulin sensitivity, and blood

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June 26, 2025 No Comments