Well Referenced

Tag: ozone therapy

Ozonized autohemotransfusion improves hemorheological parameters and oxygen delivery to tissues in patients with peripheral occlusive arterial disease

This 2001 randomized controlled trial titled “Ozonized autohemotransfusion improves hemorheological parameters and oxygen delivery to tissues in patients with peripheral occlusive arterial disease” (Annals of Hematology, DOI: [10.1007/s002770100377*) evaluated the impact of ozonized autohemotransfusion in 27 patients with peripheral occlusive arterial disease (POAD) compared to 20 healthy controls. Patients receiving

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June 26, 2025 No Comments

Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options

This randomized controlled trial compared the efficacy of intra-articular injections of platelet-rich plasma (PRP), hyaluronic acid (HA), and ozone in treating knee osteoarthritis (OA). The study involved 90 patients who received one of the three treatments and were evaluated for pain, function, and mobility over 12 weeks. Results showed that

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June 26, 2025 No Comments

Molecular effects of ozone on amino acids and proteins, especially human hemoglobin and albumin, and the need to personalize ozone concentration in major ozone autohemotherapy

This retrospective controlled cohort study evaluated intravenous (IV) ozonized saline therapy as a prophylactic intervention for healthcare workers (HCWs) in a COVID-19 hospital in India. Among 235 HCWs, 64 received ozone therapy in addition to standard prophylaxis, while 171 received standard prophylaxis only. The incidence of COVID-19 was significantly lower

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June 26, 2025 No Comments

Personalizing the safe, appropriate and effective concentration(s) of ozone for a non-diabetic individual and four type II diabetic patients in autohemotherapy through blood hemoglobin analysis

This 2019 in vitro study titled “Personalizing the Safe, Appropriate and Effective Concentration(s) of Ozone for a Non-Diabetic Individual and Four Type II Diabetic Patients in Autohemotherapy through Blood Hemoglobin Analysis” (Journal of Translational Medicine, DOI: [10.1186/s12967-019-1973-5*) investigated how different concentrations of ozone affect the structural and functional integrity of

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June 26, 2025 No Comments

Oxygen-ozone autohemotherapy in breast cancer patients suffering from fatigue and musculoskeletal pain upon aromatase inhibitors treatment: a case-series study

This review investigates the molecular impacts of ozone on hemoglobin and albumin, particularly in the context of major ozonated autohemotherapy. It explains that ozone dissolves in plasma and reacts rapidly with biomolecules to produce hydrogen peroxide and lipid oxidation products (LOPs), which serve as signaling molecules. These messengers can trigger

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June 26, 2025 No Comments

Possible Therapeutic Effects of Ozone Mixture on Hypoxia in Tumor Development

This 2017 narrative review titled “Possible Therapeutic Effects of Ozone Mixture on Hypoxia in Tumor Development” (Anticancer Research, DOI: [10.21873/anticanres.11334*) examined the role of ozone therapy as an adjunct in oncology, focusing on its ability to counteract tumor hypoxia and enhance the effectiveness of chemo-radiotherapy. The review highlighted that ozone

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June 26, 2025 No Comments

Clinical utility of ozone therapy in dental and oral medicine

This review discusses the clinical utility of ozone therapy in dental and oral medicine, highlighting its use in treating conditions such as dental caries, gingivitis, periodontitis, temporomandibular joint disorders, and post-surgical pain. Ozone therapy is effective in eliminating bacteria, promoting wound healing, and reducing inflammation, making it a valuable, non-invasive

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June 26, 2025 No Comments

Oxygen-Ozone Therapy in the Rehabilitation Field: State of the Art on Mechanisms of Action, Safety and Effectiveness in Patients with Musculoskeletal Disorders

This systematic review published in Biomolecules (2021) analyzes the safety, mechanisms of action, and efficacy of oxygen-ozone (O₂O₃) therapy in patients with musculoskeletal disorders, particularly low back pain and knee osteoarthritis. The therapy works by inducing moderate oxidative stress, which produces signaling molecules that modulate inflammation and oxidative stress pathways,

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June 26, 2025 No Comments

Sciatica: treatment with intradiscal and intraforaminal injections of steroid and oxygen-ozone versus steroid only

This 2007 randomized controlled trial titled “Sciatica: Treatment with Intradiscal and Intraforaminal Injections of Steroid and Oxygen-Ozone versus Steroid Only” (Radiology, DOI: [10.1148/radiol.2423051934*) compared the effectiveness of standard steroid/anesthetic injections with and without the addition of oxygen-ozone (O₂-O₃) therapy in 159 patients suffering from radicular pain due to acute lumbar

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June 26, 2025 No Comments

Comparison between intrarticular injection of hyaluronic acid, oxygen ozone, and the combination of both in the treatment of knee osteoarthrosis

This randomized controlled trial compared intra-articular injections of hyaluronic acid (HA), oxygen-ozone (O2O3), and their combination in treating knee osteoarthritis (OA). Seventy patients were randomized into three groups and received weekly injections over five weeks. The study found that the combination of HA and O2O3 provided superior outcomes in reducing

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June 26, 2025 No Comments