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Tag: neuroinflammation

Methylene Blue Improves Brain Mitochondrial ABAD Functions and Decreases Aβ in a Neuroinflammatory Alzheimer’s Disease Mouse Model

This study investigates the effects of methylene blue (MB) in a mouse model of Alzheimer’s disease (AD) induced by neuroinflammation. The study found that MB treatment reduced amyloid beta (Aβ) oligomers, decreased oxidative stress, and improved mitochondrial function by inhibiting the mitochondrial enzyme ABAD. Additionally, MB treatment restored brain estradiol

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June 26, 2025 No Comments

Alpha lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis

The study “Alpha Lipoic Acid Inhibits T Cell Migration into the Spinal Cord and Suppresses and Treats Experimental Autoimmune Encephalomyelitis” examined the effects of alpha lipoic acid (ALA) on experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). Administering ALA at doses of 5-100 mg/kg/day significantly reduced disease

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June 26, 2025 No Comments

Dysregulation of glutathione homeostasis in neurodegenerative diseases

The article “Dysregulation of glutathione homeostasis in neurodegenerative diseases” (Nutrients, 2012, PMID: 23201762) is a review that examines how disruptions in glutathione (GSH) balance contribute to the development and progression of neurodegenerative disorders such as Alzheimer’s, Parkinson’s, and Huntington’s diseases, as well as amyotrophic lateral sclerosis and Friedreich’s ataxia. The

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June 26, 2025 No Comments