low back pain Archives - Well Referenced

Ozone therapy as a treatment for low back pain secondary to herniated disc: a systematic review and meta-analysis of randomized controlled trials

This 2012 systematic review and meta-analysis titled “Ozone therapy as a treatment for low back pain secondary to herniated disc” (Pain Physician, PMID: [22430658]*) evaluated eight observational studies and four randomized controlled trials to assess the efficacy of percutaneous ozone injections for chronic low back pain due to disc herniation.

June 26, 2025 No Comments

The Effect of Paravertebral Ozone Injection in the Treatment of Low Back Pain

This 2019 retrospective observational study titled “The Effect of Paravertebral Ozone Injection in the Treatment of Low Back Pain” (Pain Practice, DOI: [10.1111/papr.12812*) evaluated the impact of paravertebral ozone/oxygen injections on 62 patients with chronic low back pain. Patients received 50 mL of a 15 µg/mL ozone mixture weekly for

June 26, 2025 No Comments

Comparative evaluation of oxygen-ozone therapy and combined use of oxygen-ozone therapy with percutaneous intradiscal radiofrequency thermocoagulation for the treatment of lumbar disc herniation

This randomized controlled trial compared the effectiveness of oxygen-ozone therapy alone versus a combination of oxygen-ozone therapy and percutaneous intradiscal radiofrequency thermocoagulation (PIRFT) for the treatment of lumbar disc herniation. The study showed that both treatments significantly reduced pain and disability, but the combination therapy (ozone-PIRFT) led to superior outcomes

June 26, 2025 No Comments

Effectiveness of intradiscal ozone injections for treating pain following herniated lumbar disc: A systematic review and meta-analysis

This meta-analysis evaluated the effectiveness of intradiscal ozone injections for treating pain caused by herniated lumbar discs (HLDs). The results showed that ozone injections provided superior pain relief compared to steroid injections and conventional medications, with significant improvements in pain scores at both 6 and 12 months. The therapy demonstrated

June 26, 2025 No Comments

Efficacy of Intradiscal Ozone Therapy with or without Periforaminal Steroid Injection on Lumbar Disc Herniation: A Double-Blinded Controlled Study

This randomized controlled trial evaluated the effectiveness of intradiscal ozone therapy, with or without periforaminal steroid injection, in treating lumbar disc herniation (LDH) and associated low back and leg pain. The study included 65 patients who were divided into two groups: one received only ozone therapy, and the other received

June 26, 2025 No Comments

Implication of Two Different Doses of Intradiscal Ozone-Oxygen Injection upon the Pain Alleviation in Patients with Low Back Pain: A Randomized, Single-Blind Study

This study evaluated the efficacy of two different doses of intradiscal ozone-oxygen injections for pain management in patients with low back pain caused by lumbar disc herniation. Sixty patients were divided into two groups and treated with either 40 µg/mL or 30 µg/mL ozone-oxygen mixtures. Both doses resulted in significant

June 26, 2025 No Comments

Intradiscal O2O3: Rationale, Injection Technique, Short- and Long-term Outcomes for the Treatment of Low Back Pain Due to Disc Herniation

This article examines the use of intradiscal oxygen-ozone (O2O3) therapy for treating low back pain (LBP) caused by disc herniation, particularly in cases that do not respond to conservative treatments. It highlights the safety and efficacy of O2O3 therapy, which reduces disc volume through dehydration and offers significant pain relief

June 26, 2025 No Comments

Intramuscular oxygen-ozone therapy in the treatment of acute back pain with lumbar disc herniation: a multicenter, randomized, double-blind, clinical trial of active and simulated lumbar paravertebral injection

This randomized controlled trial investigates the use of intramuscular oxygen-ozone (O2O3) therapy in treating acute low back pain (LBP) due to lumbar disc herniation. The study included 60 participants, with those receiving active O2O3 therapy showing significant improvements in pain reduction, disability, and reliance on pain medication compared to the

June 26, 2025 No Comments

Intramuscular oxygen-ozone therapy in the treatment of low back pain

This study evaluates the efficacy of intramuscular oxygen-ozone therapy for treating low back pain (LBP) using paravertebral ozone injections. A total of 109 patients were treated, with 67 completing the study. Results showed that 79% of patients experienced a significant reduction in pain (VAS reduction by 2.3 points) and improvement

June 26, 2025 No Comments

Intramuscular paravertebral oxygen-ozone therapy for chronic neck pain and low back pain: evaluation of 6-month clinical outcomes

This study evaluates the effects of oxygen-ozone therapy for chronic neck and low back pain, using intramuscular paravertebral injections over a 6-month period. It found significant improvements in pain reduction, disability, and quality of life, with a reduction in analgesic drug consumption. The therapy was safe and minimally invasive, offering

June 26, 2025 No Comments

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