This review examines the efficacy of testosterone replacement therapy (TRT) in improving male sexual function, particularly libido, erectile function, and overall sexual satisfaction, with a focus on hypogonadal men (testosterone levels below 12 nmol/L). While TRT has proven beneficial in enhancing these aspects, its impact on orgasmic function remains inconclusive.
This meta-analysis examined the effects of testosterone supplementation on male sexual function, finding that testosterone therapy significantly improved sexual function in hypogonadal men, while its role in men without clear hypogonadism remains uncertain. The study also noted differences in results between industry-supported and independent trials, attributing these to trial design
This systematic review examines the effects of testosterone therapy (TTh) on erectile dysfunction (ED) and libido in hypogonadal men. The findings suggest that TTh significantly improves erectile function, particularly in men with mild ED or those who do not respond to phosphodiesterase type 5 inhibitors. It also enhances libido in
A meta-analysis published in Mayo Clinic Proceedings reviewed randomized placebo-controlled trials to evaluate the effects of testosterone therapy on sexual dysfunction in men. The study found that testosterone therapy significantly improved sexual desire and erectile function compared to placebo, though the effect sizes were modest and varied across studies. No
This article examines the issue of low libido in postmenopausal women, highlighting hormonal changes such as a decline in estrogen and testosterone levels as major contributors. It discusses how hormone replacement therapy (HRT) and lifestyle modifications can improve libido in affected women, offering a potential treatment strategy for enhancing sexual
This article reviews the use of testosterone supplementation for libido enhancement in postmenopausal women, noting that while it provides benefits, there are concerns about its potential to increase breast cancer risk due to the conversion of testosterone into oestradiol. The article calls for more high-quality studies to assess long-term safety.
This study reviews testosterone therapy for hypoactive sexual desire disorder (HSDD) in women, assessing its benefits and risks, especially following the introduction of PDE5 inhibitors. The article highlights that while testosterone may improve libido, its safety and long-term effects remain inconclusive. Several studies have explored this treatment, but no standardized
The article “Disorders of Orgasm in Women” by Cindy M. Meston et al., published in the Journal of Sexual Medicine (PMID: 16422985), reviews Female Orgasmic Disorder (FOD), a condition characterized by persistent or recurrent delay or absence of orgasm following normal sexual excitement, leading to distress or interpersonal difficulty. The
This study on testosterone replacement therapy (TRT) in hypogonadal men highlights significant improvements in sexual function, mood, and energy levels. The randomized controlled trial (RCT) demonstrated symptom relief in men with hypogonadism, showing enhanced sexual desire, reduced depressive symptoms, and better overall mood. These findings underline the clinical relevance of
