Well Referenced

Tag: libido

Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss

This 2016 observational study published in the Journal of Clinical Endocrinology & Metabolism (PMID: 27662439) evaluated men who reported persistent sexual symptoms after discontinuing finasteride for androgenetic alopecia. The study found no evidence of ongoing androgen deficiency or 5α-reductase inhibition, but symptomatic users displayed depressed mood and functional MRI changes

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June 26, 2025 No Comments

Persistent sexual side effects of finasteride: could they be permanent?

This observational study published in the Journal of Sexual Medicine (2012, PMID: 22789024) evaluated 54 otherwise healthy young men who developed persistent sexual side effects after discontinuing finasteride, a 5-alpha-reductase inhibitor used for male pattern baldness. Despite an average of 14 months off the medication, 96% of participants reported ongoing

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June 26, 2025 No Comments

Safety and efficacy of a testosterone metered-dose transdermal spray for treating decreased sexual satisfaction in premenopausal women: a randomized trial

This randomized controlled trial evaluated the safety and effectiveness of a testosterone metered-dose transdermal spray in premenopausal women aged 35–46 with decreased sexual satisfaction and low serum-free testosterone levels. A daily dose of 90-μL significantly increased satisfactory sexual events compared to placebo (2.48 vs. 1.70 events, p=0.04). The most common

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June 26, 2025 No Comments

Monoamines and neurosteroids in sexual function during induced hypogonadism in healthy men

The study “Monoamines and neurosteroids in sexual function during induced hypogonadism in healthy men” examined the effects of induced hypogonadism on sexual function and its relationship with cerebrospinal fluid (CSF) levels of neurosteroids and monoamine metabolites. In this comparative study, healthy male volunteers received the gonadotropin-releasing hormone agonist leuprolide acetate

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June 26, 2025 No Comments

The current outlook for testosterone in the management of hypoactive sexual desire disorder in postmenopausal women

A review published in The Journal of Sexual Medicine examined the role of testosterone therapy in managing hypoactive sexual desire disorder (HSDD) in postmenopausal women. The study found that testosterone treatment significantly improves sexual desire and satisfaction in this population. However, potential side effects such as hirsutism and acne were

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June 26, 2025 No Comments

The use of androgens for female sexual dysfunction

This article explores the use of androgen therapy in addressing female sexual dysfunction, highlighting the role of androgens in female sexual health, libido, and overall well-being. It evaluates clinical evidence supporting androgen therapy, including its potential benefits in improving sexual desire and function, while also addressing associated risks. The study

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June 26, 2025 No Comments

Which Postmenopausal Women Should Use Testosterone for Low Sexual Desire?

The article “Which Postmenopausal Women Should Use Testosterone for Low Sexual Desire?” published in JAMA (2020) examines the criteria for prescribing testosterone therapy to postmenopausal women experiencing hypoactive sexual desire disorder (HSDD). It discusses the efficacy and safety of testosterone treatment, emphasizing the need for accurate diagnosis and individualized patient

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June 26, 2025 No Comments

Symptomatic response rates to testosterone therapy and the likelihood of completing 12 months of therapy in clinical practice

This cohort study evaluates the symptomatic response and adherence to testosterone therapy (TTh) in men with testosterone deficiency. The study involved 127 men, with most reporting improvements in erectile function, libido, energy, and mood within 3 months. By 12 months, 63% of the participants continued therapy with sustained benefits. However,

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June 26, 2025 No Comments

Testosterone and Sexual Function

This review explores the impact of testosterone replacement therapy (TRT) on sexual function, particularly in men with hypogonadism, mixed conditions, or even those with normal testosterone levels. It highlights that TRT significantly improves sexual function outcomes such as libido, erectile function, and ejaculatory function, though the degree of improvement varies

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June 26, 2025 No Comments

Testosterone Replacement Therapy for Sexual Symptoms

This review examines the efficacy of testosterone replacement therapy (TRT) in improving male sexual function, particularly libido, erectile function, and overall sexual satisfaction, with a focus on hypogonadal men (testosterone levels below 12 nmol/L). While TRT has proven beneficial in enhancing these aspects, its impact on orgasmic function remains inconclusive.

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June 26, 2025 No Comments