Well Referenced

Tag: integrative oncology

Cost-effectiveness of real-world administration of chemotherapy and add-on Viscum album L. therapy compared to chemotherapy in the treatment of stage IV NSCLC patients

This observational study assessed the cost-effectiveness of adding Viscum album L. (mistletoe extract) to standard chemotherapy in patients with stage IV non-small cell lung cancer (NSCLC). Among 118 patients (mean age 63.8, 55.1% male), those receiving Viscum album plus chemotherapy had a longer adjusted mean overall survival (19.1 months) compared

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June 26, 2025 No Comments

Efficacy and safety of long-term complementary treatment with standardized European mistletoe extract (Viscum album L.) in addition to the conventional adjuvant oncologic therapy in patients with primary non-metastasized mammary carcinoma. Results of a multi-center, comparative, epidemiological cohort study in Germany and Switzerland

This multicenter, retrospective cohort study evaluated the long-term safety and effectiveness of standardized European mistletoe extract (Viscum album L., Iscador) as an adjuvant to conventional oncologic therapy in 1,442 patients with primary non-metastasized breast cancer (UICC stage I–III). Over a median follow-up of 67 months, patients receiving mistletoe extract in

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June 26, 2025 No Comments

Evaluation of quality of life in lung cancer patients receiving radiation and Viscum album L.: a real-world data study

This 2023 observational study (Radiation Oncology, PMID: 36879290) evaluated 112 lung cancer patients, primarily with non-small-cell lung cancer (median age 70), to assess the impact of adjunctive Viscum album L. (mistletoe) therapy on quality of life (QoL) during standard treatments, including radiation. Over 12 months, patients receiving radiation plus VA

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June 26, 2025 No Comments

Targeting the Mitochondrial-Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol

This review article introduces the mitochondrial-stem cell connection (MSCC) theory, suggesting that cancer originates from chronic oxidative phosphorylation (OxPhos) dysfunction in stem cells, leading to the formation of cancer stem cells (CSCs). The proposed hybrid orthomolecular protocol integrates orthomolecules (e.g., vitamins C and D, zinc), repurposed drugs (e.g., ivermectin, benzimidazoles),

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June 26, 2025 No Comments

Combination of High-Dose Parenteral Ascorbate (Vitamin C) and Alpha-Lipoic Acid Failed to Enhance Tumor-Inhibitory Effect But Increased Toxicity in Preclinical Cancer Models

This preclinical study investigated the combined effects of high-dose intravenous vitamin C (ascorbate, Asc) and alpha-lipoic acid (ALA) on six human cancer cell lines and a mouse model of metastatic breast cancer. While high-dose Asc alone demonstrated tumor-inhibitory effects without toxicity, ALA did not inhibit tumor growth and instead increased

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June 26, 2025 No Comments