This 2013 review explores the dual role of the growth hormone (GH)–insulin–insulin-like growth factor-1 (IGF-1) signaling pathway in aging and cancer. In juveniles, GH promotes growth and sexual maturation; however, in adults, elevated GH/IGF-1 levels are associated with increased risks of cancer, insulin resistance, and diabetes. Studies in various organisms,
This 2020 review explores how caloric restriction (CR) and caloric restriction mimetics (CRMs) enhance healthspan and lifespan through modulation of key nutrient-sensing pathways, including IGF-1, mTOR, and AMPK. CR has been associated with improved metabolic parameters, reduced inflammation, and extended lifespan in multiple species. CRMs—such as resveratrol, metformin, and rapamycin—aim
This randomized controlled trial investigated the effects of continuous subcutaneous infusion of GH-releasing hormone(1-29)-NH2 (GHRH1-29-NH2) in children with growth hormone deficiency (GHD). The treatment successfully restored physiological growth hormone (GH) secretion patterns, leading to increased insulin-like growth factor 1 (IGF-1) levels and improved growth velocity. These results suggest that GHRH1-29-NH2
This 2023 review article explores the rapid and sustained antidepressant effects of ketamine, focusing on its modulation of neurotrophic and growth factors such as brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and insulin-like growth factor 1 (IGF-1). Ketamine rapidly enhances BDNF and VEGF expression in the prefrontal cortex
The review titled “DHEA in bone: the role in osteoporosis and fracture healing” (Archives of Osteoporosis, 2020, PMID: 32504237) examines the role of dehydroepiandrosterone (DHEA) in improving bone mineral density and potentially facilitating fracture healing. It highlights DHEA’s anabolic action on bone through stimulating osteoblast activity and increasing insulin-like growth
The review article titled “DHEA in bone: the role in osteoporosis and fracture healing” (Archives of Osteoporosis, 2020, PMID: 32504237) explores the potential role of dehydroepiandrosterone (DHEA) in improving bone health, particularly its effects on osteoporosis and fracture healing. DHEA, a precursor to estrogen and testosterone, has been shown to
This cohort study investigated the impact of low protein intake on IGF-1 levels, cancer risk, and overall mortality in individuals aged 50-65 and older. It found that reducing protein intake significantly lowered IGF-1 levels and was associated with a decrease in cancer and mortality risk in younger adults (≤65 years),
The study titled “Effects of hormonal changes on sarcopenia in chronic kidney disease: where are we now and what can we do?” explores the role of hormonal imbalances in the development of sarcopenia in chronic kidney disease (CKD) patients. It highlights deficiencies in testosterone, growth hormone (GH), insulin-like growth factor
