Well Referenced

Tag: flavonoids

Alcohol Use Disorders and Current Pharmacological Therapies: The Role of GABA(A) Receptors

This comprehensive review examines the involvement of GABA(A) receptors in the pathophysiology of alcohol use disorders (AUD) and evaluates current and emerging pharmacotherapies targeting these receptors. Chronic alcohol exposure leads to neuroadaptive changes in GABA(A) receptor subunit composition and function, contributing to tolerance, dependence, and withdrawal symptoms. Traditional treatments like

Read More »
June 26, 2025 No Comments

The Role of Natural Antioxidants Against Reactive Oxygen Species Produced by Cadmium Toxicity: A Review

This review article explores the mechanisms by which cadmium (Cd) induces oxidative stress and evaluates the potential protective roles of natural antioxidants. Cd exposure disrupts cellular redox homeostasis through the excessive generation of reactive oxygen species (ROS), leading to damage in lipids, proteins, and DNA. The review highlights natural antioxidant

Read More »
June 26, 2025 No Comments

Biology of ageing and role of dietary antioxidants

This 2014 review examines the role of dietary antioxidants in the aging process. It highlights that while oxygen is essential for aerobic organisms, it also leads to the continuous generation of reactive oxygen species (ROS), which are implicated in aging. The body’s antioxidant defense system, comprising enzymes like superoxide dismutase

Read More »
June 26, 2025 No Comments

Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action

This narrative review discusses the powerful antioxidant properties of dietary polyphenols, found in foods like fruits, vegetables, and beverages such as tea and wine. The review highlights how these compounds help mitigate oxidative stress, which is a contributor to chronic diseases such as neurodegenerative disorders, cardiovascular diseases, cancer, diabetes, and

Read More »
June 26, 2025 No Comments

Functional Food Nutrients, Redox Resilience Signaling and Neurosteroids for Brain Health

This systematic review explores the role of functional food nutrients, such as flavonoids (curcumin, resveratrol), probiotics, vitamin D, and omega-3 fatty acids, in enhancing brain health by modulating oxidative stress and neuroinflammation through the Nrf2 antioxidant pathway. These nutrients activate protective genes like HO-1 and Sirt1, helping to maintain neurosteroid

Read More »
June 26, 2025 No Comments

Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy

This systematic review explores the health benefits of polyphenols, which are abundant in foods like fruits, vegetables, tea, and coffee. Polyphenols have demonstrated antioxidant properties and have been shown to prevent and manage chronic diseases such as obesity, atherosclerosis, diabetes, hypertension, cancer, and neurological disorders. The review discusses the mechanisms

Read More »
June 26, 2025 No Comments

Phytochemical and Pharmacological Activity Profile of Crataegus oxyacantha L. (Hawthorn) – A Cardiotonic Herb

This review article explores the cardiotonic herb Crataegus oxyacantha (hawthorn), highlighting its pharmacological and phytochemical properties that support cardiovascular health. It discusses how the plant’s active constituents—such as oligomeric procyanidins and flavonoids—contribute to improved coronary blood flow, exercise tolerance, and modulation of cardiac function through positive inotropic and negative chronotropic

Read More »
June 26, 2025 No Comments

Beneficial action of resveratrol: How and why?

This review article explores the wide-ranging health benefits of resveratrol, focusing on its anti-inflammatory, anticancer, and neuroprotective properties. Resveratrol modulates several biological pathways, including NF-κB, cyclooxygenase enzymes, apoptosis pathways, and the AMPK pathway, leading to its beneficial effects on inflammation, metabolism, and neurological health. The article highlights resveratrol’s potential in

Read More »
June 26, 2025 No Comments

Bioactive Compounds from Vegetal Organs of Taraxacum Species (Dandelion) with Biomedical Applications: A Review

This review explores the bioactive compounds found in Taraxacum officinale (dandelion), such as polyphenols, flavonoids, carotenoids, terpenes, and coumarins, which contribute to its therapeutic properties. The review highlights dandelion’s anti-inflammatory, anticancer, antimicrobial, antioxidant, hepatoprotective, and antidiabetic effects, demonstrating its potential in managing conditions like inflammation, cancer, infections, oxidative stress, liver

Read More »
June 26, 2025 No Comments

Review article: the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases

This study explores the role of oxidative stress in the pathogenesis and treatment of inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis. It highlights how reactive oxygen species (ROS) contribute to intestinal inflammation, mucosal damage, and increased risk of colitis-associated colorectal cancer. The article reviews antioxidant therapies, including

Read More »
June 26, 2025 No Comments