Well Referenced

Tag: fibromyalgia

The possibilities of using the effects of ozone therapy in neurology

This 2021 narrative review titled “The Possibilities of Using the Effects of Ozone Therapy in Neurology” (Neuro Endocrinology Letters, PMID: [33932964]*) explored the diverse therapeutic applications of ozone therapy across neurological, cardiovascular, musculoskeletal, infectious, and dermatological conditions. The review highlighted ozone’s ability to stimulate antioxidant defenses, improve blood circulation, modulate

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June 26, 2025 No Comments

Intravenous Micronutrient Therapy (Myers’ Cocktail) for Fibromyalgia: A Placebo-Controlled Pilot Study

This randomized, double-blind, placebo-controlled pilot study evaluated the safety, feasibility, and preliminary efficacy of intravenous micronutrient therapy (IVMT), specifically the Myers’ Cocktail, in 34 adults with ACR-defined fibromyalgia. Participants received weekly infusions of either IVMT or placebo over 8 weeks. Both groups showed within-group improvements, but no statistically significant differences

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June 26, 2025 No Comments

Increased gut permeability and bacterial translocation are associated with fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome: implications for disease-related biomarker discovery

This 2023 observational study published in Frontiers in Immunology (PMID: 37744357) examined the link between intestinal permeability, bacterial translocation, and the presence of fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In 78 participants (22 FM, 30 ME/CFS, 26 healthy controls), FM patients showed significantly elevated plasma levels of anti-beta-lactoglobulin

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June 26, 2025 No Comments

Coenzyme Q10 supplementation alleviates pain in pregabalin-treated fibromyalgia patients via reducing brain activity and mitochondrial dysfunction

This clinical trial investigated the effects of Coenzyme Q10 (CoQ10) supplementation on pain reduction in fibromyalgia patients receiving pregabalin. The study found that adding CoQ10 to pregabalin therapy significantly reduced pain, improved mitochondrial function, and decreased brain hyperactivity, suggesting a synergistic effect in managing fibromyalgia symptoms. CoQ10, a key component

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June 26, 2025 No Comments

Reduction of fibromyalgia symptoms through intravenous nutrient therapy: results of a pilot clinical trial

This pilot clinical study evaluated the effects of intravenous nutrient therapy (modified Myers’ Cocktail) in seven patients with therapy-resistant fibromyalgia. Over eight weeks, participants received weekly infusions and reported significant reductions in pain (60%) and fatigue (80%) (p=0.005), along with noticeable improvements in energy and daily functioning within 24–48 hours

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June 26, 2025 No Comments

Double-blind, multicenter trial comparing acetyl l- carnitine with placebo in the treatment of fibromyalgia patients

This randomized controlled trial evaluated the efficacy of acetyl l-carnitine (LAC) in treating fibromyalgia syndrome (FMS) compared to placebo in 102 patients. The study involved an initial two-week intramuscular LAC administration (500 mg/day), followed by oral supplementation (1,500 mg/day) for eight weeks. Results showed significant improvements in pain reduction, depression,

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June 26, 2025 No Comments

Dehydroepiandrosterone (DHEA) Supplementation in Rheumatic Diseases: A Systematic Review

The systematic review titled “Dehydroepiandrosterone (DHEA) Supplementation in Rheumatic Diseases” (Mediterranean Journal of Rheumatology, 2023, DOI: 10.31138/mjr.20230825.dd) evaluated the effectiveness of DHEA in patients with systemic lupus erythematosus (SLE), Sjögren’s syndrome (SS), rheumatoid arthritis (RA), and fibromyalgia (FM) across 21 studies. DHEA supplementation notably improved bone mineral density, reduced fatigue,

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June 26, 2025 No Comments

Hyperbaric oxygen therapy compared to pharmacological intervention in fibromyalgia patients following traumatic brain injury: A randomized, controlled trial

This randomized controlled trial evaluated the effects of hyperbaric oxygen therapy (HBOT) on fibromyalgia patients with a history of traumatic brain injury (TBI). The study found that HBOT significantly reduced pain intensity, improved quality of life, and enhanced emotional and social functioning compared to pharmacological treatment. Brain imaging revealed increased

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June 26, 2025 No Comments

Double-blind, randomized, placebo-controlled crossover trial of alpha-lipoic acid for the treatment of fibromyalgia pain: the IMPALA trial

The study titled Double-blind, randomized, placebo-controlled crossover trial of alpha-lipoic acid for the treatment of fibromyalgia pain: the IMPALA trial, published in Pain (2021), investigated the efficacy of alpha-lipoic acid (ALA) in reducing pain among fibromyalgia patients. This randomized controlled trial found that ALA significantly reduced pain scores compared to

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June 26, 2025 No Comments