Well Referenced

Tag: fatigue

Inflammation and behavioral symptoms after breast cancer treatment: do fatigue, depression, and sleep disturbance share a common underlying mechanism?

This observational study examined 103 women who recently completed early-stage breast cancer treatment, finding that over 60% experienced fatigue and sleep disturbances, and 25% showed elevated depressive symptoms. Chemotherapy was associated with higher levels of fatigue, sleep problems, depressive symptoms, and increased levels of the inflammatory marker sTNF-RII (all P

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June 26, 2025 No Comments

Inflammatory, Oxidative Stress, and Cardiac Damage Biomarkers and Radiation-Induced Fatigue in Breast Cancer Survivors

This 2022 observational study (PMID: 35527686) published in Biological Research for Nursing explored the relationship between biomarkers of inflammation, oxidative stress, and cardiac damage with post-treatment fatigue in 180 postmenopausal breast cancer survivors who had undergone radiation therapy. The researchers found that higher levels of cystatin-C, IL-6, and GDF-15 were

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June 26, 2025 No Comments

Serum sTNF-R1, IL-6, and the development of fatigue in patients with gastrointestinal cancer undergoing chemoradiation therapy

This cohort study of 103 patients with gastrointestinal cancers undergoing concurrent chemoradiation therapy (CXRT) found that elevated levels of inflammatory markers—soluble tumor necrosis factor receptor 1 (sTNF-R1) and interleukin-6 (IL-6)—were significantly associated with worsening fatigue and other symptoms such as pain, drowsiness, and poor appetite during treatment. Both markers increased

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June 26, 2025 No Comments

Anemia in Older Adults

This review article discusses the evaluation and management of anemia in older adults, a condition associated with increased morbidity and mortality. It highlights that anemia is frequently asymptomatic but can present with fatigue, weakness, or shortness of breath. Common causes include iron deficiency, chronic kidney disease, inflammation, and gastrointestinal blood

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June 26, 2025 No Comments

Feasibility of Vitamin C in the Treatment of Post Viral Fatigue with Focus on Long COVID, Based on a Systematic Review of IV Vitamin C on Fatigue

This systematic review examined the effectiveness and feasibility of high-dose intravenous (IV) vitamin C in treating fatigue, particularly in post-viral contexts such as long COVID. Across nine studies with 720 participants, three of four controlled trials and four of five observational studies showed a significant reduction in fatigue levels in

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June 26, 2025 No Comments

Reduction of fibromyalgia symptoms through intravenous nutrient therapy: results of a pilot clinical trial

This pilot clinical study evaluated the effects of intravenous nutrient therapy (modified Myers’ Cocktail) in seven patients with therapy-resistant fibromyalgia. Over eight weeks, participants received weekly infusions and reported significant reductions in pain (60%) and fatigue (80%) (p=0.005), along with noticeable improvements in energy and daily functioning within 24–48 hours

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June 26, 2025 No Comments

Lessons Learned from a Rhode Island Academic Out-Patient Lyme and Tick-Borne Disease Clinic

This observational study reviewed 218 patient charts from a Rhode Island outpatient Lyme and tick-borne disease clinic, highlighting the challenges in diagnosing and managing post-treatment Lyme disease syndrome (PTLDS). Common symptoms included fatigue (66.5%), joint pain (58.2%), cognitive difficulties (32.1%), and headaches (27.9%). Over half of the patients with symptoms

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June 26, 2025 No Comments