The review article titled “DHEA in bone: the role in osteoporosis and fracture healing” (Archives of Osteoporosis, 2020, PMID: 32504237) explores the potential role of dehydroepiandrosterone (DHEA) in improving bone health, particularly its effects on osteoporosis and fracture healing. DHEA, a precursor to estrogen and testosterone, has been shown to
The article “The endocrine system and ageing” discusses the hormonal changes that occur with aging, including declines in estrogen, testosterone, growth hormone, and other key hormones, as well as increases in certain others like luteinizing hormone and sex hormone-binding globulin. These alterations contribute to various clinical consequences such as reduced
The article “The influence of estrogen on skeletal muscle: sex matters” reviews the role of estrogen in skeletal muscle function and its sex-specific effects. It discusses how estrogen can improve muscle contractile properties, reduce muscle damage after exercise, and modulate inflammation. Animal studies suggest estrogen has protective effects on muscle
This observational study examined the effects of hormone replacement therapy (HRT) on cognitive performance in postmenopausal women, analyzing data from the Danish MONICA study. It found that current users of HRT experienced less decline in concentration and visuomotor function compared to non-users. Women who started HRT during the study demonstrated
This observational study examined sexual dysfunction (SD) in peri- and postmenopausal women, assessing its incidence, pharmacological treatment options, and associated risks. Findings indicate that SD increases with age and worsens during menopause, with systemic hormone therapies (estrogen, estrogen/progesterone, estrogen/testosterone, and tibolone) improving symptoms. Local estrogen treatments effectively relieve vaginal dryness
This article emphasizes the importance of addressing sexual health within primary care settings, highlighting its role in uncovering underlying health conditions. The World Health Organization defines sexual health as encompassing physical, emotional, mental, and sexual well-being. The study discusses how sexual dysfunction in men may indicate conditions such as depression,
This observational study explores the impact of menopause on gut microbiome composition and diversity, highlighting how declining estrogen and progesterone levels lead to reduced microbial diversity and shifts in bacterial populations. Post-menopausal women exhibit lower levels of beneficial bacteria (e.g., Firmicutes, Ruminococcus) and increased potentially harmful bacteria (e.g., Prevotella, Bilophila),
This review discusses the management of menopausal symptoms, focusing on the effectiveness of hormonal and non-hormonal treatments. It highlights that systemic estrogen therapy is the most effective treatment for managing vasomotor symptoms, providing a 75% reduction in symptoms. However, it also addresses the associated risks, including increased chances of stroke,
This cohort study analyzed the relationship between different formulations of menopausal hormone therapy (HT) and breast cancer risk, finding that estrogen-only therapies (both bioidentical and animal-derived) did not significantly increase breast cancer risk, while synthetic progestins were more strongly associated with an increased risk. The study highlights a 12% increased
This study explores the relationship between nocturia and menopause, emphasizing how hormonal changes, particularly decreased estrogen and progesterone, contribute to increased nocturia symptoms in middle-aged women. The review highlights that other factors, such as obesity, diabetes, and hypertension, also play significant roles in worsening symptoms. Management strategies like hormone replacement
