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Tag: ERK

Cellular Signaling Pathways Modulated by Low-Intensity Extracorporeal Shock Wave Therapy

This 2019 review elucidates the molecular mechanisms by which low-intensity extracorporeal shock wave therapy (Li-ESWT) exerts therapeutic effects, particularly in erectile dysfunction (ED). Li-ESWT promotes neovascularization, tissue regeneration, and anti-inflammatory responses through mechanotransduction, leading to activation of key signaling pathways such as FAK, ERK1/2, Wnt/β-catenin, PI3K/Akt/mTOR, and PERK/ATF4. These pathways

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June 26, 2025 No Comments

Quercetin inhibits transcriptional up-regulation of histamine H1 receptor via suppressing protein kinase C-δ/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells

This study investigated quercetin’s ability to modulate histamine H1 receptor (H1R) gene expression in HeLa cells and its effects on allergy-like symptoms in TDI-sensitized rats. Quercetin suppressed histamine- and PMA-induced up-regulation of H1R by inhibiting PKC-δ activation and its translocation, reducing allergy-like symptoms in rats. In vivo, it also decreased

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June 26, 2025 No Comments

Glutamine and arginine improve permeability and tight junction protein expression in methotrexate-treated Caco-2 cells

This in vitro study explored the effects of glutamine and arginine on intestinal barrier function in Caco-2 cells treated with methotrexate (MTX), a chemotherapy agent that induces intestinal damage. Glutamine, arginine, and a few other amino acids were shown to restore the intestinal barrier integrity, as evidenced by improved transepithelial

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June 26, 2025 No Comments