Well Referenced

Tag: cohort study

Safety and efficacy of the long-term adjuvant treatment of primary intermediate- to high-risk malignant melanoma (UICC/AJCC stage II and III) with a standardized fermented European mistletoe (Viscum album L.) extract. Results from a multicenter, comparative, epidemiological cohort study in Germany and Switzerland

This multicenter, comparative cohort study evaluated the long-term use of fermented European mistletoe extract (Iscador) as an adjuvant therapy in patients with intermediate- to high-risk malignant melanoma (UICC/AJCC stage II-III). The treatment group, receiving subcutaneous mistletoe 2-3 times per week, showed improved tumor-related survival, better disease-free survival, and fewer brain

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June 26, 2025 No Comments

Serum interleukin-6 is an indicator for severity in 901 patients with SARS-CoV-2 infection: a cohort study

This cohort study of 901 patients with confirmed COVID-19 found that elevated serum interleukin-6 (IL-6) levels strongly correlate with disease severity and mortality. Critical cases had significantly higher IL-6 concentrations (median 21.55 pg/ml) than severe or common cases (P < 0.001), and IL-6 levels above 37.65 pg/ml predicted in-hospital mortality

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June 26, 2025 No Comments

Soluble TNFR1 has greater reproducibility than IL-6 for the assessment of chronic inflammation in older adults: the case for a new inflammatory marker in aging

This cohort study evaluated the reliability of serum biomarkers for chronic inflammation (CI) in older adults, comparing soluble tumor necrosis factor receptor 1 (sTNFR1) with interleukin-6 (IL-6). Results showed that sTNFR1 had significantly greater reproducibility over time, with intra-class correlation coefficients (ICC) of 0.95 at 6 weeks and 0.79 at

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June 26, 2025 No Comments

The relation between healthy lifestyle changes and decrease in systemic inflammation in patients with stable cardiovascular disease

This cohort study examined how lifestyle modifications—such as smoking cessation, weight loss, increased physical activity, and alcohol moderation—affect systemic inflammation, as measured by C-reactive protein (CRP) levels, in patients with stable cardiovascular disease (CVD). The study found that smoking cessation, weight loss, and physical activity significantly reduced CRP levels, with

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June 26, 2025 No Comments

Chronic low-grade inflammation associated with higher risk and earlier onset of cardiometabolic multimorbidity in middle-aged and older adults: a population-based cohort study

This cohort study investigates the relationship between chronic low-grade inflammation and the risk of early onset cardiometabolic multimorbidity in middle-aged and older adults. The study found that higher levels of inflammation were significantly linked to an increased risk of conditions such as hypertension, diabetes, and cardiovascular disease, with participants showing

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June 26, 2025 No Comments

Ten-year association of coronary artery calcium with atherosclerotic cardiovascular disease (ASCVD) events: the multi-ethnic study of atherosclerosis (MESA)

This cohort study from the Multi-Ethnic Study of Atherosclerosis (MESA) evaluated the association between coronary artery calcium (CAC) scores and the 10-year risk of atherosclerotic cardiovascular disease (ASCVD) events in 6,783 participants from diverse ethnic backgrounds. The findings demonstrated that individuals with CAC scores of 0 had ASCVD event rates

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June 26, 2025 No Comments

Associations of dietary choline intake with risk of incident dementia and with cognitive performance: the Kuopio Ischaemic Heart Disease Risk Factor Study

This cohort study examined the association between dietary choline intake, particularly phosphatidylcholine, and dementia risk in 2,497 middle-aged and older men in eastern Finland over a 21.9-year follow-up. Men in the highest quartile of phosphatidylcholine intake had a 28% lower risk of developing dementia compared to those in the lowest

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June 26, 2025 No Comments