This systematic review and meta-analysis examined the impact of mistletoe extract on the quality of life (QoL) in cancer patients, analyzing data from 26 publications and 30 datasets. The results showed a moderate improvement in global QoL, with a pooled standardized mean difference (SMD) of 0.61 (95% CI 0.47–0.75), suggesting
This systematic review evaluates the health benefits and safety of resveratrol, a polyphenolic compound found in plants, based on over 244 clinical trials. Resveratrol has shown promise in improving outcomes for a variety of chronic conditions, including diabetes, obesity, certain cancers, metabolic syndrome, hypertension, Alzheimer’s disease, stroke, cardiovascular diseases, kidney
This 2025 review article published in Physiology (Bethesda) (DOI: 10.1152/physiol.00021.2024) explores low-grade chronic inflammation (LGCI) as a central mechanism underlying a wide range of chronic diseases, including obesity, cardiovascular conditions, digestive disorders, and cancer. It explains that unresolved or persistent inflammatory stimuli can result in LGCI, which in turn promotes
This review article from Frontiers in Immunology explores the role of C-reactive protein (CRP) as a biomarker of inflammation and its potential as a therapeutic target in various chronic diseases such as cardiovascular disease, cancer, and autoimmune disorders. Elevated CRP levels have been linked to worse clinical outcomes, prompting interest
This systematic review explores the dual roles of glutathione in cancer biology, where it acts as both a protective antioxidant and a factor contributing to chemotherapy resistance in tumor cells. Elevated glutathione levels in cancer cells enable them to neutralize chemotherapeutic agents, reducing drug efficacy and complicating cancer treatment. By
The article “Glutathione Dysregulation and the Etiology and Progression of Human Diseases” explores how disruptions in glutathione (GSH) balance contribute to the onset and development of numerous diseases, including cancer, neurodegenerative conditions, cardiovascular disorders, inflammatory and immune diseases, metabolic syndromes, and age-related illnesses. Glutathione is critical in maintaining redox homeostasis
This systematic review examines the role of oxidative stress and mitochondrial dysfunction in a wide range of chronic diseases, including neurodegenerative disorders, cardiovascular disease, metabolic syndrome, cancer, and age-related conditions. The review underscores the damaging cycle of reactive oxygen species (ROS) and mitochondrial impairment, which drives cellular decline. It highlights
This review explores the role of oxidative nucleic acid damage biomarkers, specifically 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanosine (8-oxoG), in disease detection and drug development. Elevated levels of these biomarkers, found at 1.3 to 5 times higher in patients than controls, have been linked to various diseases, including cancer, neurodegenerative disorders, and
