This 2012 pilot study assessed the lipid-lowering effects of berberine in obese human subjects and Sprague-Dawley rats. Participants received 500 mg of berberine orally three times daily for 12 weeks. In humans, berberine administration resulted in a significant reduction in triglyceride levels by 23% and total cholesterol by 12.2%, along
This 2020 systematic review and meta-analysis evaluated the effects of berberine supplementation on obesity-related parameters, inflammation, and liver function enzymes. Analyzing 12 randomized controlled trials, the study found that berberine intake led to significant reductions in body weight (mean difference: -2.07 kg), body mass index (BMI), waist circumference, and C-reactive
This comprehensive review explores the role of Traditional Chinese Medicine (TCM) in managing metabolic syndrome (MetS). It introduces TCM principles and evaluates 25 traditional Chinese herbs for their potential therapeutic effects on MetS components, including obesity, insulin resistance, dyslipidemia, and hypertension. Notably, ginseng (Panax ginseng and Panax quinquefolium) exhibits anti-hyperglycemic,
This 2017 review synthesizes current evidence on how specific dietary components influence brown adipose tissue (BAT) activation and the browning of white adipose tissue (WAT), processes that enhance thermogenesis and energy expenditure. The authors highlight several dietary molecules, including phytochemicals like capsaicin, resveratrol, curcumin, green tea catechins, and berberine; dietary
This 2012 systematic review and meta-analysis assessed the efficacy and safety of berberine in managing type 2 diabetes mellitus (T2DM). Analyzing 14 randomized controlled trials involving 1,068 participants, the study found that berberine significantly improved glycemic control and lipid profiles compared to lifestyle modifications or placebo. When compared to standard
This 2011 review by Han et al. explores the hypothesis that berberine’s antidiabetic effects may be mediated through modulation of the gut microbiota. Berberine, a plant alkaloid with known antimicrobial properties, is poorly absorbed in the gastrointestinal tract, suggesting its primary action is localized within the gut. The authors propose
This 2022 study investigated the effects of berberine (BBR) on atherosclerosis through modulation of the gut microbiota. BBR was found to reduce the production of trimethylamine N-oxide (TMAO), a metabolite associated with atherosclerosis, by down-regulating the choline-TMA-TMAO pathway. The mechanism involves BBR’s metabolite, dihydroberberine (dhBBR), which inhibits key enzymes in
This study investigates the effects of berberine on human hepatoma cell invasion and its impact on healthy hepatocytes. The findings show that berberine effectively inhibits the invasive behavior of hepatoma cells, a key factor in liver cancer metastasis, without causing cytotoxicity to normal hepatocytes. These results suggest that berberine may
This study evaluates the effectiveness of berberine in preventing the recurrence of colorectal adenoma compared to a placebo. The multicenter, double-blinded, randomized controlled trial showed that berberine significantly reduced the recurrence rate of colorectal adenomas. The results suggest that berberine may serve as an effective adjunctive treatment in reducing the
This 2017 review discusses the roles of resveratrol (RES), curcumin (CUR), and berberine (BBR) in modulating aging, cancer progression, cancer stem cells (CSCs), and microRNA (miR) expression. RES activates sirtuins (e.g., SIRT1), influencing aging and cancer-related pathways. CUR exhibits anti-inflammatory and anti-cancer properties, particularly against CSCs, by affecting gene methylation
