This 2013 perspective article revisits the pioneering work of Élie Metchnikoff, who in the early 20th century proposed that health could be enhanced and aging delayed by manipulating the intestinal microbiome with beneficial bacteria found in fermented foods like yogurt. Metchnikoff’s theories, which included concepts such as bacterial translocation and
This 2021 observational study published in Frontiers in Endocrinology (PMID: 34975767) explored the connection between intestinal barrier dysfunction and Graves’ disease (GD). In 91 patients with GD compared to 44 healthy controls, researchers found significantly elevated serum levels of lipopolysaccharide (LPS), intestinal fatty acid-binding protein (I-FABP), zonulin, and D-lactate (p
This 2023 observational study published in Frontiers in Immunology (PMID: 37744357) examined the link between intestinal permeability, bacterial translocation, and the presence of fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). In 78 participants (22 FM, 30 ME/CFS, 26 healthy controls), FM patients showed significantly elevated plasma levels of anti-beta-lactoglobulin
This 2022 systematic review published in the International Journal of Molecular Sciences (PMID: 35328624) evaluates dietary, supplemental, probiotic, and pharmacological strategies to prevent bacterial translocation in individuals with leaky gut syndrome. The review emphasizes that compromised intestinal permeability allows microbial components to enter systemic circulation, promoting inflammation and contributing to
This 2018 systematic review published in Current Topics in Medicinal Chemistry (PMID: 30430944) examines the role of increased intestinal permeability—commonly referred to as leaky gut—in the development of neuroimmune disorders such as major depressive disorder (MDD), chronic fatigue syndrome (CFS), schizophrenia, and irritable bowel syndrome (IBS). The review highlights a
