Well Referenced

Tag: ALA

α-lipoic acid in patients with autosomal dominant polycystic kidney disease

The study titled “α-lipoic acid in patients with autosomal dominant polycystic kidney disease” (Nutrition, 2020, PMID: 31790890) investigated the effects of α-lipoic acid (ALA) supplementation on systemic inflammation, endothelial dysfunction, and atherosclerosis in patients with autosomal dominant polycystic kidney disease (ADPKD). In a six-month intervention, 33 patients received 1.6 g

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June 26, 2025 No Comments

Analysis of the clinical characteristics of insulin autoimmune syndrome induced by alpha-lipoic acid

The study titled “Analysis of the clinical characteristics of insulin autoimmune syndrome induced by alpha-lipoic acid” (Journal of Clinical Pharmacy and Therapeutics, 2021, PMID: 33821530) investigated 37 patients (28 females, 9 males, median age 61) who developed insulin autoimmune syndrome (IAS) after taking alpha-lipoic acid (ALA). Symptoms of hypoglycemia primarily

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June 26, 2025 No Comments

Assessment of adverse reactions to α-lipoic acid containing dietary supplements through spontaneous reporting systems

The study titled “Assessment of adverse reactions to α-lipoic acid containing dietary supplements through spontaneous reporting systems” (Clinical Nutrition, 2021, PMID: 32778460) is an observational study analyzing 116 reports of adverse reactions (ARs) to α-lipoic acid (ALA) supplements collected by the Italian Phytovigilance System from 2002 to 2020. The majority

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June 26, 2025 No Comments

Decrypting the potential role of α-lipoic acid in Alzheimer’s disease

The article titled “Decrypting the potential role of α-lipoic acid in Alzheimer’s disease” (Life Sciences, 2021, PMID: 34450170) reviews the neuroprotective effects of alpha-lipoic acid (α-LA) in Alzheimer’s disease (AD), which is characterized by amyloid-β plaques, tau protein accumulation, oxidative stress, and mitochondrial dysfunction. The review highlights α-LA’s antioxidant, antiapoptotic,

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June 26, 2025 No Comments

Double-blind, randomized, placebo-controlled crossover trial of alpha-lipoic acid for the treatment of fibromyalgia pain: the IMPALA trial

The study titled Double-blind, randomized, placebo-controlled crossover trial of alpha-lipoic acid for the treatment of fibromyalgia pain: the IMPALA trial, published in Pain (2021), investigated the efficacy of alpha-lipoic acid (ALA) in reducing pain among fibromyalgia patients. This randomized controlled trial found that ALA significantly reduced pain scores compared to

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June 26, 2025 No Comments

Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study

The study titled “Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study” (PMID: 17604563) investigated the effects of 600 mg/day alpha-lipoic acid (ALA) supplementation over three months on individuals with peripheral arterial disease (PAD). This randomized controlled trial found that ALA improved walking tolerance and delayed the

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June 26, 2025 No Comments

Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil

This in vitro study, published in Archives of Toxicology (2015, PMID: 25526924), examined the effects of alpha-lipoic acid (LA) on colorectal cancer (CRC) cells, demonstrating that LA induces cell death regardless of p53 status and enhances the cytotoxic effects of 5-fluorouracil (5-FU). Conducted on various CRC cell lines, the study

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June 26, 2025 No Comments

Protective effects of alpha-lipoic acid on bleomycin-induced skin fibrosis through the repression of NADPH Oxidase 4 and TGF-β1/Smad3 signaling pathways

This study explores the protective effects of alpha-lipoic acid (ALA) on bleomycin-induced skin fibrosis in a rat model, focusing on its role in reducing oxidative stress and inflammation. ALA treatment significantly decreased skin thickness and hydroxyproline content, indicating reduced fibrosis severity. Biochemical analyses showed ALA lowered malondialdehyde (MDA) levels, a

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June 26, 2025 No Comments