Well Referenced

Tag: ALA

n-3 Fatty Acids: Role in Neurogenesis and Neuroplasticity

This 2013 review outlines the neurobiological roles of n-3 polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and alpha-linolenic acid (ALA), in promoting adult neurogenesis and synaptic plasticity. These omega-3 fatty acids support brain function through antioxidant, anti-inflammatory, and anti-apoptotic actions. They enhance neurogenesis in the hippocampal

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June 26, 2025 No Comments

Lipoic acid induces p53-independent cell death in colorectal cancer cells and potentiates the cytotoxicity of 5-fluorouracil

This in vitro study, published in Archives of Toxicology (2015, PMID: 25526924), examined the effects of alpha-lipoic acid (LA) on colorectal cancer (CRC) cells, demonstrating that LA induces cell death regardless of p53 status and enhances the cytotoxic effects of 5-fluorouracil (5-FU). Conducted on various CRC cell lines, the study

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June 26, 2025 No Comments

Protective effects of alpha-lipoic acid on bleomycin-induced skin fibrosis through the repression of NADPH Oxidase 4 and TGF-β1/Smad3 signaling pathways

This study explores the protective effects of alpha-lipoic acid (ALA) on bleomycin-induced skin fibrosis in a rat model, focusing on its role in reducing oxidative stress and inflammation. ALA treatment significantly decreased skin thickness and hydroxyproline content, indicating reduced fibrosis severity. Biochemical analyses showed ALA lowered malondialdehyde (MDA) levels, a

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June 26, 2025 No Comments

Review article: the role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases

This study explores the role of oxidative stress in the pathogenesis and treatment of inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis. It highlights how reactive oxygen species (ROS) contribute to intestinal inflammation, mucosal damage, and increased risk of colitis-associated colorectal cancer. The article reviews antioxidant therapies, including

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June 26, 2025 No Comments

Role of lipoic acid in multiple sclerosis

The article titled “Role of lipoic acid in multiple sclerosis” (CNS Neuroscience & Therapeutics, 2022, PMID: 34964271) is a systematic review analyzing the pharmacokinetics, efficacy, safety, and mechanisms of lipoic acid (LA) in multiple sclerosis (MS). It reviews 20 studies on LA effects in cell and mouse models of MS

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June 26, 2025 No Comments

Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies

The study titled “Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies” (Antioxidants (Basel), 2020, PMID: 33086555) assessed the safety of α-lipoic acid (ALA) supplementation by analyzing data from 71 randomized placebo-controlled trials involving 4,749 participants (2,558 receiving ALA and 2,294 on placebo).

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June 26, 2025 No Comments