A single-blind, placebo-controlled crossover study examined the effects of dehydroepiandrosterone (DHEA) administration on 24-hour plasma cortisol levels in healthy older adults. Participants received either a placebo or 200 mg of oral DHEA daily for 15 days. The study found that DHEA administration significantly reduced plasma cortisol concentrations, with a more
The article “The endocrine system and ageing” discusses the hormonal changes that occur with aging, including declines in estrogen, testosterone, growth hormone, and other key hormones, as well as increases in certain others like luteinizing hormone and sex hormone-binding globulin. These alterations contribute to various clinical consequences such as reduced
This study explored the response to very low doses of recombinant human growth hormone (rhGH) in aging individuals. It found that despite the natural decline in Insulin-Like Growth Factor I (IGF-I) levels associated with aging, the peripheral sensitivity to rhGH remained intact. The study demonstrated that even at low doses,
This observational study examined the effects of hormone replacement therapy (HRT) on cognitive performance in postmenopausal women, analyzing data from the Danish MONICA study. It found that current users of HRT experienced less decline in concentration and visuomotor function compared to non-users. Women who started HRT during the study demonstrated
This systematic review examines population-based studies assessing the impact of menopause on women’s sexual functioning, distinguishing between age-related and menopause-specific declines. Findings indicate that sexual dysfunction increases with menopausal transition, as seen in the Melbourne Women’s Midlife Health Project, where rates rose from 42% in early menopause to 88% in
This review examines the role of androgens and estrogens in aging, focusing on their impact on muscle mass, bone density, and overall physical function. In men, declining testosterone levels are linked to reduced muscle mass, bone density, and strength, while in women, estradiol deficiency primarily affects bone health, with less
This systematic review examines the potential benefits of hyperbaric oxygen therapy (HBOT) for promoting healthy aging. It explores HBOT’s mechanisms, including its effects on oxidative stress, cellular senescence, and aging-related diseases. The review highlights preclinical and clinical studies suggesting that HBOT may improve age-related conditions by reducing oxidative stress and
This study investigated the effects of hyperbaric oxygen therapy (HBOT) on telomere length and immunosenescence, showing that HBOT increased telomere length and reduced immune cell senescence in adults aged 50-80 years. With 40 sessions of HBOT over 2 months, the results suggested a significant enhancement in cellular aging and immune
This randomized controlled trial investigated the effects of testosterone and growth hormone (GH) supplementation on body composition and muscle performance in older men. The study involved 122 men aged 70.8 years with low testosterone and IGF-I levels. The results showed that testosterone and GH supplementation increased lean body mass by
This review explores the relationship between testosterone levels and cognitive function in elderly men, highlighting potential neuroprotective effects observed in cell culture and animal studies. While some observational studies suggest an association between higher testosterone levels and better memory and executive function, human research remains inconsistent. Low free testosterone levels
