Well Referenced

Category: Exercise & Physical Performance

Exercise optimization, injury prevention, and physical rehabilitation.

GH feedback occurs through modulation of hypothalamic somatostatin under cholinergic control: studies with pyridostigmine and GHRH

This randomized controlled trial examined the role of cholinergic modulation in growth hormone (GH) secretion, specifically investigating how pyridostigmine, a cholinesterase inhibitor, influences GH release through suppression of hypothalamic somatostatin. Pyridostigmine significantly increased GH secretion by enhancing cholinergic activity, which reduced somatostatin’s inhibitory effects, thereby promoting GH release. Though specific

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June 26, 2025 No Comments

Magnesium supplementation enhances mTOR signalling to facilitate myogenic differentiation and improve aged muscle performance

This cohort study investigated the effects of magnesium supplementation on muscle performance and myogenic differentiation in older adults. It found that magnesium supplementation enhanced mTOR signaling, which is essential for muscle protein synthesis, leading to improved muscle strength, function, and tissue regeneration in individuals aged 60-75. The supplementation significantly improved

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June 26, 2025 No Comments

Hawthorn extract for treating chronic heart failure

This systematic review assessed the effects of hawthorn extract as an adjunctive treatment for chronic heart failure (CHF), analyzing data from 14 randomized, double-blind, placebo-controlled trials involving 855 patients. The findings showed that hawthorn extract significantly improved exercise tolerance, increased maximal workload, reduced the pressure-heart rate product, and alleviated symptoms

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June 26, 2025 No Comments

Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms–results of an open-label study

This open-label observational study assessed the effects of Rhodiola rosea extract WS® 1375 on individuals with life-stress symptoms. A total of 101 participants took 200 mg of the extract twice daily for four weeks. Improvements in stress, fatigue, functional impairment, and overall well-being were observed as early as day 3

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June 26, 2025 No Comments

Can Magnesium Enhance Exercise Performance?

This 2017 systematic review examined the effects of magnesium (Mg) on exercise performance, analyzing both animal and human studies. The findings suggest that magnesium supplementation can enhance physical performance by improving glucose availability, reducing lactate accumulation, and supporting muscle energy metabolism. In human studies, higher magnesium status correlated with better

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June 26, 2025 No Comments

Health Behavior Combinations and Their Association With Inflammation

This observational study examined how combinations of healthy behaviors—including regular physical activity, a balanced diet, and smoking abstinence—are associated with lower systemic inflammation as measured by C-reactive protein (CRP). Individuals practicing multiple healthy behaviors demonstrated significantly reduced CRP levels, suggesting that a comprehensive lifestyle approach is more effective in mitigating

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June 26, 2025 No Comments

Lifestyle deterioration linked to elevated inflammatory cytokines over a two-month follow-up

This 2024 observational study published in Scientific Reports (DOI: 10.1038/s41598-024-69967-3) examined the impact of lifestyle changes on inflammation over a two-month period in 179 healthy individuals. Researchers found that a decline in lifestyle quality—especially reduced physical activity—was significantly associated with increased levels of inflammatory cytokines IL-17A and IFN-γ. Specifically, a

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June 26, 2025 No Comments

Modifiable lifestyle risk factors and C-reactive protein in patients with coronary artery disease: Implications for an anti-inflammatory treatment target population

This 2021 observational study published in the European Journal of Preventive Cardiology (DOI: 10.1177/2047487319885458) examined the link between modifiable lifestyle risk factors (modRFs) and systemic inflammation, measured via high-sensitivity C-reactive protein (hsCRP), in 1,014 patients with coronary artery disease (CAD). Nearly half of the patients had elevated hsCRP levels (≥2

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June 26, 2025 No Comments

The Association of Anti-Inflammatory Diet Ingredients and Lifestyle Exercise with Inflammaging

This observational study examined the relationship between anti-inflammatory diet components, physical activity, and markers of chronic low-grade inflammation (“inflammaging”) in 60 Polish adults aged 65 and older. Participants with lower levels of inflammation (LGI group) had higher intake of vitamin D, a more favorable n-6/n-3 PUFA ratio, and better physical

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June 26, 2025 No Comments

The Challenge by Multiple Environmental and Biological Factors Induce Inflammation in Aging: Their Role in the Promotion of Chronic Disease

This review article explores how environmental and biological factors—such as pollution, poor nutrition, oxidative stress, and psychosocial stress—contribute to “inflammaging,” a chronic low-grade inflammatory state associated with aging. While genetic predisposition plays a minor role, the authors highlight that environmental exposures are key drivers of age-related inflammation and chronic diseases.

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June 26, 2025 No Comments